2rk7: Difference between revisions

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{{Seed}}
[[Image:2rk7.png|left|200px]]


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==The Structure of rat cytosolic PEPCK in complex with oxalate==
The line below this paragraph, containing "STRUCTURE_2rk7", creates the "Structure Box" on the page.
<StructureSection load='2rk7' size='340' side='right'caption='[[2rk7]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2rk7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RK7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RK7 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=OXL:OXALATE+ION'>OXL</scene></td></tr>
{{STRUCTURE_2rk7| PDB=2rk7 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rk7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rk7 OCA], [https://pdbe.org/2rk7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rk7 RCSB], [https://www.ebi.ac.uk/pdbsum/2rk7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rk7 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PCKGC_RAT PCKGC_RAT] Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rk/2rk7_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rk7 ConSurf].
<div style="clear:both"></div>


===The Structure of rat cytosolic PEPCK in complex with oxalate===
==See Also==
 
*[[Phosphoenolpyruvate carboxykinase 3D structures|Phosphoenolpyruvate carboxykinase 3D structures]]
 
__TOC__
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The line below this paragraph, {{ABSTRACT_PUBMED_18197707}}, adds the Publication Abstract to the page
[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_18197707}}
 
==About this Structure==
2RK7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RK7 OCA].
 
==Reference==
Differential Inhibition of Cytosolic PEPCK by Substrate Analogues. Kinetic and Structural Characterization of Inhibitor Recognition., Stiffin RM, Sullivan SM, Carlson GM, Holyoak T, Biochemistry. 2008 Feb 19;47(7):2099-109. Epub 2008 Jan 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18197707 18197707]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Single protein]]
[[Category: Carlson GM]]
[[Category: Carlson, G M.]]
[[Category: Holyoak T]]
[[Category: Holyoak, T.]]
[[Category: Stiffin RM]]
[[Category: Stiffin, R M.]]
[[Category: Sullivan SM]]
[[Category: Sullivan, S M.]]
[[Category: Cytoplasm]]
[[Category: Decarboxylase]]
[[Category: Gluconeogenesis]]
[[Category: Gtp-binding]]
[[Category: Kinase]]
[[Category: Lyase]]
[[Category: Nucleotide-binding]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 01:40:39 2008''

Latest revision as of 12:22, 21 February 2024

The Structure of rat cytosolic PEPCK in complex with oxalateThe Structure of rat cytosolic PEPCK in complex with oxalate

Structural highlights

2rk7 is a 2 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.9Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PCKGC_RAT Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2rk7, resolution 1.90Å

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