2rj9: Difference between revisions

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{{Seed}}
[[Image:2rj9.png|left|200px]]


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==B-specific alpha-1,3-galactosyltransferase (GTB) + UDP+ Amino-deoxy-acceptor==
The line below this paragraph, containing "STRUCTURE_2rj9", creates the "Structure Box" on the page.
<StructureSection load='2rj9' size='340' side='right'caption='[[2rj9]], [[Resolution|resolution]] 1.69&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2rj9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RJ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RJ9 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.69&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AD7:OCTYL+3-AMINO-3-DEOXY-2-O-(2,6-DIDEOXY-ALPHA-L-LYXO-HEXOPYRANOSYL)-BETA-D-GALACTOPYRANOSIDE'>AD7</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
{{STRUCTURE_2rj9| PDB=2rj9 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rj9 OCA], [https://pdbe.org/2rj9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rj9 RCSB], [https://www.ebi.ac.uk/pdbsum/2rj9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rj9 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BGAT_HUMAN BGAT_HUMAN] This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rj/2rj9_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rj9 ConSurf].
<div style="clear:both"></div>


===B-specific alpha-1,3-galactosyltransferase (GTB) + UDP+ Amino-deoxy-acceptor===
==See Also==
 
*[[Glycosyltransferase 3D structures|Glycosyltransferase 3D structures]]
 
__TOC__
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</StructureSection>
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{{ABSTRACT_PUBMED_18192272}}
 
==Disease==
Known disease associated with this structure: Blood group, ABO system OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=110300 110300]]
 
==About this Structure==
2RJ9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RJ9 OCA].
 
==Reference==
ABO(H) blood group A and B glycosyltransferases recognize substrate via specific conformational changes., Alfaro JA, Zheng RB, Persson M, Letts JA, Polakowski R, Bai Y, Borisova SN, Seto NO, Lowary TL, Palcic MM, Evans SV, J Biol Chem. 2008 Jan 11;. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18192272 18192272]
[[Category: Fucosylgalactoside 3-alpha-galactosyltransferase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Alfaro, J A.]]
[[Category: Alfaro JA]]
[[Category: Evans, S V.]]
[[Category: Evans SV]]
[[Category: Blood group antigen]]
[[Category: Glycoprotein]]
[[Category: Glycosyltransferase]]
[[Category: Golgi apparatus]]
[[Category: Gtb abo rossman fold bbbb + udp + ada]]
[[Category: Manganese]]
[[Category: Membrane]]
[[Category: Metal-binding]]
[[Category: Polymorphism]]
[[Category: Secreted]]
[[Category: Signal-anchor]]
[[Category: Transferase]]
[[Category: Transmembrane]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:41:09 2008''

Latest revision as of 12:22, 21 February 2024

B-specific alpha-1,3-galactosyltransferase (GTB) + UDP+ Amino-deoxy-acceptorB-specific alpha-1,3-galactosyltransferase (GTB) + UDP+ Amino-deoxy-acceptor

Structural highlights

2rj9 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.69Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

BGAT_HUMAN This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2rj9, resolution 1.69Å

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