2rj9: Difference between revisions

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[[Image:2rj9.png|left|200px]]


{{STRUCTURE_2rj9|  PDB=2rj9  |  SCENE=  }}
==B-specific alpha-1,3-galactosyltransferase (GTB) + UDP+ Amino-deoxy-acceptor==
 
<StructureSection load='2rj9' size='340' side='right'caption='[[2rj9]], [[Resolution|resolution]] 1.69&Aring;' scene=''>
===B-specific alpha-1,3-galactosyltransferase (GTB) + UDP+ Amino-deoxy-acceptor===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2rj9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RJ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RJ9 FirstGlance]. <br>
{{ABSTRACT_PUBMED_18192272}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.69&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AD7:OCTYL+3-AMINO-3-DEOXY-2-O-(2,6-DIDEOXY-ALPHA-L-LYXO-HEXOPYRANOSYL)-BETA-D-GALACTOPYRANOSIDE'>AD7</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rj9 OCA], [https://pdbe.org/2rj9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rj9 RCSB], [https://www.ebi.ac.uk/pdbsum/2rj9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rj9 ProSAT]</span></td></tr>
[[2rj9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RJ9 OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/BGAT_HUMAN BGAT_HUMAN] This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rj/2rj9_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rj9 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Galactosyltransferase|Galactosyltransferase]]
*[[Glycosyltransferase 3D structures|Glycosyltransferase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:018192272</ref><references group="xtra"/>
[[Category: Fucosylgalactoside 3-alpha-galactosyltransferase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Alfaro, J A.]]
[[Category: Large Structures]]
[[Category: Evans, S V.]]
[[Category: Alfaro JA]]
[[Category: Blood group antigen]]
[[Category: Evans SV]]
[[Category: Glycoprotein]]
[[Category: Glycosyltransferase]]
[[Category: Golgi apparatus]]
[[Category: Gtb abo rossman fold bbbb + udp + ada]]
[[Category: Manganese]]
[[Category: Membrane]]
[[Category: Metal-binding]]
[[Category: Secreted]]
[[Category: Signal-anchor]]
[[Category: Transferase]]
[[Category: Transmembrane]]

Latest revision as of 12:22, 21 February 2024

B-specific alpha-1,3-galactosyltransferase (GTB) + UDP+ Amino-deoxy-acceptorB-specific alpha-1,3-galactosyltransferase (GTB) + UDP+ Amino-deoxy-acceptor

Structural highlights

2rj9 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.69Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

BGAT_HUMAN This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2rj9, resolution 1.69Å

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