2rj6: Difference between revisions

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[[Image:2rj6.png|left|200px]]


{{STRUCTURE_2rj6|  PDB=2rj6  |  SCENE=  }}
==B-specific alpha-1,3-galactosyltransferase G176R S235G mutant (AABB) + H-antigen disaccharide==
 
<StructureSection load='2rj6' size='340' side='right'caption='[[2rj6]], [[Resolution|resolution]] 1.41&Aring;' scene=''>
===B-specific alpha-1,3-galactosyltransferase G176R S235G mutant (AABB) + H-antigen disaccharide===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2rj6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RJ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RJ6 FirstGlance]. <br>
{{ABSTRACT_PUBMED_18192272}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.41&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BHE:OCTYL+2-O-(6-DEOXY-ALPHA-L-GALACTOPYRANOSYL)-BETA-D-GALACTOPYRANOSIDE'>BHE</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rj6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rj6 OCA], [https://pdbe.org/2rj6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rj6 RCSB], [https://www.ebi.ac.uk/pdbsum/2rj6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rj6 ProSAT]</span></td></tr>
[[2rj6]] is a 1 chain structure of [[Galactosyltransferase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RJ6 OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/BGAT_HUMAN BGAT_HUMAN] This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rj/2rj6_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rj6 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Galactosyltransferase|Galactosyltransferase]]
*[[Glycosyltransferase 3D structures|Glycosyltransferase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:018192272</ref><references group="xtra"/>
[[Category: Fucosylgalactoside 3-alpha-galactosyltransferase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Alfaro, J A.]]
[[Category: Large Structures]]
[[Category: Evans, S V.]]
[[Category: Alfaro JA]]
[[Category: Aabb+ha]]
[[Category: Evans SV]]
[[Category: Blood group antigen]]
[[Category: Glycoprotein]]
[[Category: Glycosyltransferase]]
[[Category: Golgi apparatus]]
[[Category: Manganese]]
[[Category: Membrane]]
[[Category: Metal-binding]]
[[Category: Secreted]]
[[Category: Signal-anchor]]
[[Category: Transferase]]
[[Category: Transmembrane]]

Latest revision as of 12:22, 21 February 2024

B-specific alpha-1,3-galactosyltransferase G176R S235G mutant (AABB) + H-antigen disaccharideB-specific alpha-1,3-galactosyltransferase G176R S235G mutant (AABB) + H-antigen disaccharide

Structural highlights

2rj6 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.41Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

BGAT_HUMAN This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2rj6, resolution 1.41Å

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