2rig: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:2rig.jpg|left|200px]]<br /><applet load="2rig" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="2rig, resolution 2.3&Aring;" />
-'''CRYSTAL STRUCTURE OF RECOMBINANT RABBIT INTERFERON-GAMMA AT 2.7-ANGSTROMS RESOLUTION'''<br />
-==Overview==
+==CRYSTAL STRUCTURE OF RECOMBINANT RABBIT INTERFERON-GAMMA AT 2.7-ANGSTROMS RESOLUTION==
-The crystal structure of recombinant rabbit interferon-gamma was solved by, the multiple isomorphous replacement technique at 2.7-A resolution and, refined to a crystallographic R-factor of 26.2%. The interferon, crystallizes with one-half of the functional dimer in the asymmetric unit, with the two polypeptide chains of the dimer related by a crystallographic, 2-fold symmetry axis. The structure is predominantly alpha-helical with, extensive interdigitation of the alpha-helical segments of the two, polypeptide chains.
+<StructureSection load='2rig' size='340' side='right'caption='[[2rig]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2rig]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1rig 1rig]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RIG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RIG FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rig OCA], [https://pdbe.org/2rig PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rig RCSB], [https://www.ebi.ac.uk/pdbsum/2rig PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rig ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/IFNG_RABIT IFNG_RABIT] Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ri/2rig_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rig ConSurf].
+<div style="clear:both"></div>
-==About this Structure==
+==See Also==
-RIG is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. This structure superseeds the now removed PDB entry 1RIG. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2RIG OCA].
+*[[Interferon 3D structures|Interferon 3D structures]]
+__TOC__
-==Reference==
+</StructureSection>
-Crystal structure of recombinant rabbit interferon-gamma at 2.7-A resolution., Samudzi CT, Burton LE, Rubin JR, J Biol Chem. 1991 Nov 15;266(32):21791-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=1939201 1939201]
+[[Category: Large Structures]]
 [[Category: Oryctolagus cuniculus]]
-[[Category: Single protein]]
+[[Category: Burton LE]]
-[[Category: Burton, L.E.]]
+[[Category: Rubin JR]]
-[[Category: Rubin, J.R.]]
+[[Category: Samudzi CT]]
-[[Category: Samudzi, C.T.]]
-[[Category: cytokine]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 13:57:36 2007''