2rig: Difference between revisions

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-[[Image:2rig.jpg|left|200px]]
-<!--
+==CRYSTAL STRUCTURE OF RECOMBINANT RABBIT INTERFERON-GAMMA AT 2.7-ANGSTROMS RESOLUTION==
-The line below this paragraph, containing "STRUCTURE_2rig", creates the "Structure Box" on the page.
+<StructureSection load='2rig' size='340' side='right'caption='[[2rig]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2rig]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1rig 1rig]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RIG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RIG FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rig OCA], [https://pdbe.org/2rig PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rig RCSB], [https://www.ebi.ac.uk/pdbsum/2rig PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rig ProSAT]</span></td></tr>
-{{STRUCTURE_2rig|  PDB=2rig  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/IFNG_RABIT IFNG_RABIT] Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ri/2rig_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rig ConSurf].
+<div style="clear:both"></div>
-'''CRYSTAL STRUCTURE OF RECOMBINANT RABBIT INTERFERON-GAMMA AT 2.7-ANGSTROMS RESOLUTION'''
+==See Also==
+*[[Interferon 3D structures|Interferon 3D structures]]
+__TOC__
-==Overview==
+</StructureSection>
-The crystal structure of recombinant rabbit interferon-gamma was solved by the multiple isomorphous replacement technique at 2.7-A resolution and refined to a crystallographic R-factor of 26.2%. The interferon crystallizes with one-half of the functional dimer in the asymmetric unit, with the two polypeptide chains of the dimer related by a crystallographic 2-fold symmetry axis. The structure is predominantly alpha-helical with extensive interdigitation of the alpha-helical segments of the two polypeptide chains.
+[[Category: Large Structures]]
-==About this Structure==
-RIG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1rig 1rig]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RIG OCA].
-==Reference==
-Crystal structure of recombinant rabbit interferon-gamma at 2.7-A resolution., Samudzi CT, Burton LE, Rubin JR, J Biol Chem. 1991 Nov 15;266(32):21791-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1939201 1939201]
 [[Category: Oryctolagus cuniculus]]
-[[Category: Single protein]]
+[[Category: Burton LE]]
-[[Category: Burton, L E.]]
+[[Category: Rubin JR]]
-[[Category: Rubin, J R.]]
+[[Category: Samudzi CT]]
-[[Category: Samudzi, C T.]]
-[[Category: Cytokine]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 16:58:14 2008''