2rfa: Difference between revisions

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-[[Image:2rfa.png|left|200px]]
-<!--
+==Crystal structure of the mouse TRPV6 ankyrin repeat domain==
-The line below this paragraph, containing "STRUCTURE_2rfa", creates the "Structure Box" on the page.
+<StructureSection load='2rfa' size='340' side='right'caption='[[2rfa]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2rfa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RFA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RFA FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rfa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rfa OCA], [https://pdbe.org/2rfa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rfa RCSB], [https://www.ebi.ac.uk/pdbsum/2rfa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rfa ProSAT]</span></td></tr>
-{{STRUCTURE_2rfa|  PDB=2rfa  |  SCENE=  }}
+</table>
+== Function ==
-===Crystal structure of the mouse TRPV6 ankyrin repeat domain===
+[https://www.uniprot.org/uniprot/TRPV6_MOUSE TRPV6_MOUSE] Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating.<ref>PMID:12601087</ref> <ref>PMID:12574114</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
-<!--
+Check<jmol>
-The line below this paragraph, {{ABSTRACT_PUBMED_18232717}}, adds the Publication Abstract to the page
+  <jmolCheckbox>
-(as it appears on PubMed at http://www.pubmed.gov), where 18232717 is the PubMed ID number.
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rf/2rfa_consurf.spt"</scriptWhenChecked>
--->
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-{{ABSTRACT_PUBMED_18232717}}
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
-==About this Structure==
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rfa ConSurf].
-[[2rfa]] is a 1 chain structure of [[Ion channels]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RFA OCA].
+<div style="clear:both"></div>
 ==See Also==
-*[[Ion channels]]
+*[[Ion channels 3D structures|Ion channels 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:18232717</ref><references group="xtra"/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Mus musculus]]
-[[Category: Gaudet, R.]]
+[[Category: Gaudet R]]
-[[Category: Huang, R J.]]
+[[Category: Huang RJ]]
-[[Category: Phelps, C B.]]
+[[Category: Phelps CB]]
-[[Category: Wang, R R.]]
+[[Category: Wang RR]]
-[[Category: Ank repeat]]
-[[Category: Ankyrin reapeat]]
-[[Category: Calcium]]
-[[Category: Calcium channel]]
-[[Category: Calcium transport]]
-[[Category: Calmodulin-binding]]
-[[Category: Glycoprotein]]
-[[Category: Ion transport]]
-[[Category: Ionic channel]]
-[[Category: Membrane]]
-[[Category: Membrane protein]]
-[[Category: Transient receptor potential]]
-[[Category: Transmembrane]]
-[[Category: Transport]]
-[[Category: Trpv6]]