2rdt: Difference between revisions

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[[Image:2rdt.png|left|200px]]


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==Crystal Structure of Human Glycolate Oxidase (GO) in Complex with CDST==
The line below this paragraph, containing "STRUCTURE_2rdt", creates the "Structure Box" on the page.
<StructureSection load='2rdt' size='340' side='right'caption='[[2rdt]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2rdt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RDT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RDT FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2RD:5-(DODECYLTHIO)-1H-1,2,3-TRIAZOLE-4-CARBOXYLIC+ACID'>2RD</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr>
{{STRUCTURE_2rdt| PDB=2rdt |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rdt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rdt OCA], [https://pdbe.org/2rdt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rdt RCSB], [https://www.ebi.ac.uk/pdbsum/2rdt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rdt ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HAOX1_HUMAN HAOX1_HUMAN] Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rd/2rdt_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rdt ConSurf].
<div style="clear:both"></div>


===Crystal Structure of Human Glycolate Oxidase (GO) in Complex with CDST===
==See Also==
 
*[[Glycolate oxidase 3D structures|Glycolate oxidase 3D structures]]
 
__TOC__
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</StructureSection>
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{{ABSTRACT_PUBMED_18215067}}
 
==About this Structure==
2RDT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RDT OCA].
 
==Reference==
Active Site and Loop 4 Movements within Human Glycolate Oxidase: Implications for Substrate Specificity and Drug Design., Murray MS, Holmes RP, Lowther WT, Biochemistry. 2008 Feb 26;47(8):2439-49. Epub 2008 Jan 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18215067 18215067]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Holmes, R P.]]
[[Category: Holmes RP]]
[[Category: Lowther, W T.]]
[[Category: Lowther WT]]
[[Category: Murray, M S.]]
[[Category: Murray MS]]
[[Category: Flavoprotein]]
[[Category: Fmn]]
[[Category: Glycolate pathway]]
[[Category: Oxidoreductase]]
[[Category: Peroxisome]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:53:43 2008''

Latest revision as of 12:21, 21 February 2024

Crystal Structure of Human Glycolate Oxidase (GO) in Complex with CDSTCrystal Structure of Human Glycolate Oxidase (GO) in Complex with CDST

Structural highlights

2rdt is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.95Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

HAOX1_HUMAN Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2rdt, resolution 1.95Å

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