2rbe: Difference between revisions

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-{{Seed}}
-[[Image:2rbe.png|left|200px]]
-<!--
+==The discovery of 2-anilinothiazolones as 11beta-HSD1 inhibitors==
-The line below this paragraph, containing "STRUCTURE_2rbe", creates the "Structure Box" on the page.
+<StructureSection load='2rbe' size='340' side='right'caption='[[2rbe]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2rbe]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RBE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RBE FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=ZMG:(5R)-2-[(2-FLUOROPHENYL)AMINO]-5-(1-METHYLETHYL)-1,3-THIAZOL-4(5H)-ONE'>ZMG</scene></td></tr>
-{{STRUCTURE_2rbe|  PDB=2rbe  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rbe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rbe OCA], [https://pdbe.org/2rbe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rbe RCSB], [https://www.ebi.ac.uk/pdbsum/2rbe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rbe ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/DHI1_HUMAN DHI1_HUMAN] Defects in HSD11B1 are a cause of cortisone reductase deficiency (CRD) [MIM:[https://omim.org/entry/604931 604931]. In CRD, activation of cortisone to cortisol does not occur, resulting in adrenocorticotropin-mediated androgen excess and a phenotype resembling polycystic ovary syndrome (PCOS).
+== Function ==
+[https://www.uniprot.org/uniprot/DHI1_HUMAN DHI1_HUMAN] Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol (By similarity).
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rb/2rbe_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rbe ConSurf].
+<div style="clear:both"></div>
-===The discovery of 2-anilinothiazolones as 11beta-HSD1 inhibitors===
+==See Also==
+*[[Hydroxysteroid dehydrogenase 3D structures|Hydroxysteroid dehydrogenase 3D structures]]
+__TOC__
-<!--
+</StructureSection>
-The line below this paragraph, {{ABSTRACT_PUBMED_17919905}}, adds the Publication Abstract to the page
-(as it appears on PubMed at http://www.pubmed.gov), where 17919905 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_17919905}}
-==About this Structure==
-RBE is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RBE OCA].
-==Reference==
-<ref group="xtra">PMID:17919905</ref><references group="xtra"/>
-[[Category: 11-beta-hydroxysteroid dehydrogenase]]
 [[Category: Homo sapiens]]
-[[Category: Jordan, S R.]]
+[[Category: Large Structures]]
-[[Category: Li, V.]]
+[[Category: Jordan SR]]
-[[Category: Zhang, J.]]
+[[Category: Li V]]
-[[Category: Alpha beta]]
+[[Category: Zhang J]]
-[[Category: Endoplasmic reticulum]]
-[[Category: Glycoprotein]]
-[[Category: Lipid metabolism]]
-[[Category: Membrane]]
-[[Category: Microsome]]
-[[Category: Nadp]]
-[[Category: Oxidoreductase]]
-[[Category: Polymorphism]]
-[[Category: Rossmann fold]]
-[[Category: Signal-anchor]]
-[[Category: Steroid metabolism]]
-[[Category: Transmembrane]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 08:04:16 2009''