2r7l: Difference between revisions

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-[[Image:2r7l.jpg|left|200px]]
- {{Structure
+==Crystal structure of FAICAR synthetase (PurP) from M. jannaschii complexed with ATP and AICAR==
-|PDB= 2r7l |SIZE=350|CAPTION= <scene name='initialview01'>2r7l</scene>, resolution 2.10&Aring;
+<StructureSection load='2r7l' size='340' side='right'caption='[[2r7l]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND= <scene name='pdbligand=AMZ:AMINOIMIDAZOLE+4-CARBOXAMIDE+RIBONUCLEOTIDE'>AMZ</scene>, <scene name='pdbligand=ATP:ADENOSINE-5&#39;-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
+<table><tr><td colspan='2'>[[2r7l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R7L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R7L FirstGlance]. <br>
-|ACTIVITY=
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-|GENE= purP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2190 Methanocaldococcus jannaschii])
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMZ:AMINOIMIDAZOLE+4-CARBOXAMIDE+RIBONUCLEOTIDE'>AMZ</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-|DOMAIN=
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r7l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r7l OCA], [https://pdbe.org/2r7l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r7l RCSB], [https://www.ebi.ac.uk/pdbsum/2r7l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r7l ProSAT]</span></td></tr>
-|RELATEDENTRY=[[2r7k|2R7K]], [[2r7m|2R7M]], [[2r7n|2R7N]]
+</table>
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2r7l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r7l OCA], [http://www.ebi.ac.uk/pdbsum/2r7l PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2r7l RCSB]</span>
+== Function ==
-}}
+[https://www.uniprot.org/uniprot/PURP_METJA PURP_METJA] Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.<ref>PMID:15623504</ref>
+== Evolutionary Conservation ==
-'''Crystal structure of FAICAR synthetase (PurP) from M. jannaschii complexed with ATP and AICAR'''
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
-==About this Structure==
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r7/2r7l_consurf.spt"</scriptWhenChecked>
-R7L is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R7L OCA].
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r7l ConSurf].
+<div style="clear:both"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Methanocaldococcus jannaschii]]
-[[Category: Single protein]]
+[[Category: Ealick SE]]
-[[Category: Ealick, S E.]]
+[[Category: White RH]]
-[[Category: White, R H.]]
+[[Category: Zhang Y]]
-[[Category: Zhang, Y.]]
-[[Category: atp-binding]]
-[[Category: atp-grasp superfamily]]
-[[Category: ligase]]
-[[Category: magnesium]]
-[[Category: manganese]]
-[[Category: metal-binding]]
-[[Category: nucleotide-binding]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:57:27 2008''