2r7l: Difference between revisions

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[[Image:2r7l.jpg|left|200px]]


{{Structure
==Crystal structure of FAICAR synthetase (PurP) from M. jannaschii complexed with ATP and AICAR==
|PDB= 2r7l |SIZE=350|CAPTION= <scene name='initialview01'>2r7l</scene>, resolution 2.10&Aring;
<StructureSection load='2r7l' size='340' side='right'caption='[[2r7l]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ATP:ADENOSINE-5&#39;-TRIPHOSPHATE'>ATP</scene> and <scene name='pdbligand=AMZ:AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE'>AMZ</scene>
<table><tr><td colspan='2'>[[2r7l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R7L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R7L FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
|GENE= purP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2190 Methanocaldococcus jannaschii])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMZ:AMINOIMIDAZOLE+4-CARBOXAMIDE+RIBONUCLEOTIDE'>AMZ</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r7l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r7l OCA], [https://pdbe.org/2r7l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r7l RCSB], [https://www.ebi.ac.uk/pdbsum/2r7l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r7l ProSAT]</span></td></tr>
 
</table>
'''Crystal structure of FAICAR synthetase (PurP) from M. jannaschii complexed with ATP and AICAR'''
== Function ==
 
[https://www.uniprot.org/uniprot/PURP_METJA PURP_METJA] Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.<ref>PMID:15623504</ref>
 
== Evolutionary Conservation ==
==About this Structure==
[[Image:Consurf_key_small.gif|200px|right]]
2R7L is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R7L OCA].  
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r7/2r7l_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r7l ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Methanocaldococcus jannaschii]]
[[Category: Methanocaldococcus jannaschii]]
[[Category: Single protein]]
[[Category: Ealick SE]]
[[Category: Ealick, S E.]]
[[Category: White RH]]
[[Category: White, R H.]]
[[Category: Zhang Y]]
[[Category: Zhang, Y.]]
[[Category: AMZ]]
[[Category: ATP]]
[[Category: CL]]
[[Category: SO4]]
[[Category: atp-binding]]
[[Category: atp-grasp superfamily]]
[[Category: ligase]]
[[Category: magnesium]]
[[Category: manganese]]
[[Category: metal-binding]]
[[Category: nucleotide-binding]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 15:48:15 2008''

Latest revision as of 12:20, 21 February 2024

Crystal structure of FAICAR synthetase (PurP) from M. jannaschii complexed with ATP and AICARCrystal structure of FAICAR synthetase (PurP) from M. jannaschii complexed with ATP and AICAR

Structural highlights

2r7l is a 1 chain structure with sequence from Methanocaldococcus jannaschii. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.1Å
Ligands:, , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PURP_METJA Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Ownby K, Xu H, White RH. A Methanocaldococcus jannaschii archaeal signature gene encodes for a 5-formaminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate synthetase. A new enzyme in purine biosynthesis. J Biol Chem. 2005 Mar 25;280(12):10881-7. Epub 2004 Dec 28. PMID:15623504 doi:http://dx.doi.org/M413937200

2r7l, resolution 2.10Å

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