2r24: Difference between revisions

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[[Image:2r24.png|left|200px]]


{{STRUCTURE_2r24|  PDB=2r24  |  SCENE=  }}
==Human Aldose Reductase structure==
 
<StructureSection load='2r24' size='340' side='right'caption='[[2r24]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
===Human Aldose Reductase structure===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2r24]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R24 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R24 FirstGlance]. <br>
{{ABSTRACT_PUBMED_18250329}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Hybrid , Neutron Diffraction , X-ray diffraction, [[Resolution|Resolution]] 1.752&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LDT:IDD594'>LDT</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r24 OCA], [https://pdbe.org/2r24 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r24 RCSB], [https://www.ebi.ac.uk/pdbsum/2r24 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r24 ProSAT]</span></td></tr>
[[2r24]] is a 1 chain structure of [[Aldose Reductase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R24 OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/ALDR_HUMAN ALDR_HUMAN] Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r2/2r24_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r24 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Aldose Reductase|Aldose Reductase]]
*[[Aldose reductase 3D structures|Aldose reductase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:018250329</ref><references group="xtra"/>
[[Category: Aldehyde reductase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Afonine, P.]]
[[Category: Large Structures]]
[[Category: Blakeley, M P.]]
[[Category: Afonine P]]
[[Category: Cachau, R.]]
[[Category: Blakeley MP]]
[[Category: Cousido-Siah, A.]]
[[Category: Cachau R]]
[[Category: Ginell, S.]]
[[Category: Cousido-Siah A]]
[[Category: Haertlein, M.]]
[[Category: Ginell S]]
[[Category: Hazemann, I.]]
[[Category: Haertlein M]]
[[Category: Joachimiak, A.]]
[[Category: Hazemann I]]
[[Category: Meilleur, F.]]
[[Category: Joachimiak A]]
[[Category: Mitschler, A.]]
[[Category: Meilleur F]]
[[Category: Myles, D.]]
[[Category: Mitschler A]]
[[Category: Podjarny, A.]]
[[Category: Myles D]]
[[Category: Ruiz, F.]]
[[Category: Podjarny A]]
[[Category: Ventura, O N.]]
[[Category: Ruiz F]]
[[Category: Beta/alpha-8 tim barrel]]
[[Category: Ventura ON]]
[[Category: Cataract]]
[[Category: Nadp]]
[[Category: Oxidoreductase]]

Latest revision as of 12:19, 21 February 2024

Human Aldose Reductase structureHuman Aldose Reductase structure

Structural highlights

2r24 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Hybrid , Neutron Diffraction , X-ray diffraction, Resolution 1.752Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ALDR_HUMAN Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2r24, resolution 1.75Å

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
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