2qyk: Difference between revisions

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OCA

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-{{Seed}}
-[[Image:2qyk.png|left|200px]]
-<!--
+==Crystal structure of PDE4A10 in complex with inhibitor NPV==
-The line below this paragraph, containing "STRUCTURE_2qyk", creates the "Structure Box" on the page.
+<StructureSection load='2qyk' size='340' side='right'caption='[[2qyk]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2qyk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QYK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QYK FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NPV:4-[8-(3-NITROPHENYL)-1,7-NAPHTHYRIDIN-6-YL]BENZOIC+ACID'>NPV</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-{{STRUCTURE_2qyk|  PDB=2qyk  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qyk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qyk OCA], [https://pdbe.org/2qyk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qyk RCSB], [https://www.ebi.ac.uk/pdbsum/2qyk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qyk ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PDE4A_HUMAN PDE4A_HUMAN] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.<ref>PMID:11566027</ref> <ref>PMID:17727341</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qy/2qyk_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qyk ConSurf].
+<div style="clear:both"></div>
-===Crystal structure of PDE4A10 in complex with inhibitor NPV===
+==See Also==
+*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
+== References ==
-<!--
+<references/>
-The line below this paragraph, {{ABSTRACT_PUBMED_17727341}}, adds the Publication Abstract to the page
+__TOC__
-(as it appears on PubMed at http://www.pubmed.gov), where 17727341 is the PubMed ID number.
+</StructureSection>
--->
-{{ABSTRACT_PUBMED_17727341}}
-==About this Structure==
-QYK is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QYK OCA].
-==Reference==
-<ref group="xtra">PMID:17727341</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Chen, Y.]]
+[[Category: Large Structures]]
-[[Category: Geng, J.]]
+[[Category: Chen Y]]
-[[Category: Houslay, M.]]
+[[Category: Geng J]]
-[[Category: Peng, M.]]
+[[Category: Houslay M]]
-[[Category: Robinson, H.]]
+[[Category: Peng M]]
-[[Category: Wang, H.]]
+[[Category: Robinson H]]
-[[Category: Hydrolase]]
+[[Category: Wang H]]
-[[Category: Pde4 inhibitor]]
-[[Category: Subfamily inhibitor selectivity]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 06:18:47 2009''