2qw9: Difference between revisions

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-{{Seed}}
-[[Image:2qw9.png|left|200px]]
-<!--
+==Crystal structure of bovine hsc70 (1-394aa)in the apo state==
-The line below this paragraph, containing "STRUCTURE_2qw9", creates the "Structure Box" on the page.
+<StructureSection load='2qw9' size='340' side='right'caption='[[2qw9]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2qw9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QW9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QW9 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-{{STRUCTURE_2qw9|  PDB=2qw9  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qw9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qw9 OCA], [https://pdbe.org/2qw9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qw9 RCSB], [https://www.ebi.ac.uk/pdbsum/2qw9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qw9 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/HSP7C_BOVIN HSP7C_BOVIN] Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex (By similarity).
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qw/2qw9_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qw9 ConSurf].
+<div style="clear:both"></div>
-===Crystal structure of bovine hsc70 (1-394aa)in the apo state===
+==See Also==
+*[[Heat Shock Protein structures|Heat Shock Protein structures]]
+__TOC__
-<!--
+</StructureSection>
-The line below this paragraph, {{ABSTRACT_PUBMED_17996706}}, adds the Publication Abstract to the page
-(as it appears on PubMed at http://www.pubmed.gov), where 17996706 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_17996706}}
-==About this Structure==
-QW9 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QW9 OCA].
-==Reference==
-<ref group="xtra">PMID:17996706</ref><references group="xtra"/>
 [[Category: Bos taurus]]
-[[Category: Hinck, A P.]]
+[[Category: Large Structures]]
-[[Category: Jiang, J.]]
+[[Category: Hinck AP]]
-[[Category: Lafer, E M.]]
+[[Category: Jiang J]]
-[[Category: Maes, E G.]]
+[[Category: Lafer EM]]
-[[Category: Sousa, R.]]
+[[Category: Maes EG]]
-[[Category: Taylor, A B.]]
+[[Category: Sousa R]]
-[[Category: Wang, L.]]
+[[Category: Taylor AB]]
-[[Category: Atp-binding]]
+[[Category: Wang L]]
-[[Category: Chaperone]]
-[[Category: Cytoplasm]]
-[[Category: Nucleotide-binding]]
-[[Category: Nucleus]]
-[[Category: Phosphorylation]]
-[[Category: Stress response]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 17:02:07 2009''