2qth: Difference between revisions

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<StructureSection load='2qth' size='340' side='right'caption='[[2qth]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='2qth' size='340' side='right'caption='[[2qth]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2qth]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sulfolobus_solfataricus_p2 Sulfolobus solfataricus p2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QTH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QTH FirstGlance]. <br>
<table><tr><td colspan='2'>[[2qth]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus_P2 Saccharolobus solfataricus P2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QTH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QTH FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2qtf|2qtf]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">hflX, SSO0269 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=273057 Sulfolobus solfataricus P2])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qth OCA], [https://pdbe.org/2qth PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qth RCSB], [https://www.ebi.ac.uk/pdbsum/2qth PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qth ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qth OCA], [https://pdbe.org/2qth PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qth RCSB], [https://www.ebi.ac.uk/pdbsum/2qth PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qth ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/HFLX_SULSO HFLX_SULSO]] GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Specific for GTP.[HAMAP-Rule:MF_00900]<ref>PMID:19787775</ref> <ref>PMID:21478358</ref>
[https://www.uniprot.org/uniprot/HFLX_SACS2 HFLX_SACS2] GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Specific for GTP.[HAMAP-Rule:MF_00900]<ref>PMID:19787775</ref> <ref>PMID:21478358</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Sulfolobus solfataricus p2]]
[[Category: Saccharolobus solfataricus P2]]
[[Category: Brouns, S J]]
[[Category: Brouns SJ]]
[[Category: Fu, S]]
[[Category: Fu S]]
[[Category: Oost, J Van der]]
[[Category: Rao Z]]
[[Category: Rao, Z]]
[[Category: Sun L]]
[[Category: Sun, L]]
[[Category: Van der Oost J]]
[[Category: Wu, H]]
[[Category: Wu H]]
[[Category: Beta-alpha-barrel]]
[[Category: Gtp-binding]]
[[Category: Nucleotide binding protein]]
[[Category: Nucleotide-binding]]

Latest revision as of 12:17, 21 February 2024

Crystal structure of a GTP-binding protein from the hyperthermophilic archaeon Sulfolobus solfataricus in complex with GDPCrystal structure of a GTP-binding protein from the hyperthermophilic archaeon Sulfolobus solfataricus in complex with GDP

Structural highlights

2qth is a 1 chain structure with sequence from Saccharolobus solfataricus P2. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2Å
Ligands:, , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

HFLX_SACS2 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Specific for GTP.[HAMAP-Rule:MF_00900][1] [2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Wu H, Sun L, Blombach F, Brouns SJ, Snijders AP, Lorenzen K, van den Heuvel RH, Heck AJ, Fu S, Li X, Zhang XC, Rao Z, van der Oost J. Structure of the ribosome associating GTPase HflX. Proteins. 2010 Feb 15;78(3):705-13. doi: 10.1002/prot.22599. PMID:19787775 doi:http://dx.doi.org/10.1002/prot.22599
  2. ↑ Blombach F, Launay H, Zorraquino V, Swarts DC, Cabrita LD, Benelli D, Christodoulou J, Londei P, van der Oost J. An HflX-type GTPase from Sulfolobus solfataricus binds to the 50S ribosomal subunit in all nucleotide-bound states. J Bacteriol. 2011 Jun;193(11):2861-7. doi: 10.1128/JB.01552-10. Epub 2011 Apr 8. PMID:21478358 doi:http://dx.doi.org/10.1128/JB.01552-10

2qth, resolution 2.00Å

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