2qcc: Difference between revisions

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-{{Seed}}
-[[Image:2qcc.png|left|200px]]
-<!--
+==Crystal structure of the orotidine-5'-monophosphate decarboxylase domain of human UMP synthase, apo form==
-The line below this paragraph, containing "STRUCTURE_2qcc", creates the "Structure Box" on the page.
+<StructureSection load='2qcc' size='340' side='right'caption='[[2qcc]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2qcc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QCC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QCC FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-{{STRUCTURE_2qcc|  PDB=2qcc  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qcc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qcc OCA], [https://pdbe.org/2qcc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qcc RCSB], [https://www.ebi.ac.uk/pdbsum/2qcc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qcc ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/UMPS_HUMAN UMPS_HUMAN] Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:[https://omim.org/entry/258900 258900]. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.<ref>PMID:9042911</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/UMPS_HUMAN UMPS_HUMAN]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qc/2qcc_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qcc ConSurf].
+<div style="clear:both"></div>
-===Crystal structure of the orotidine-5'-monophosphate decarboxylase domain of human UMP synthase, apo form===
+==See Also==
+*[[Uridine 5'-monophosphate synthase 3D structures|Uridine 5'-monophosphate synthase 3D structures]]
+== References ==
-<!--
+<references/>
-The line below this paragraph, {{ABSTRACT_PUBMED_18184586}}, adds the Publication Abstract to the page
+__TOC__
-(as it appears on PubMed at http://www.pubmed.gov), where 18184586 is the PubMed ID number.
+</StructureSection>
--->
-{{ABSTRACT_PUBMED_18184586}}
-==Disease==
-Known disease associated with this structure: Oroticaciduria OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=258900 258900]]
-==About this Structure==
-QCC is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QCC OCA].
-==Reference==
-<ref group="xtra">PMID:18184586</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Orotidine-5'-phosphate decarboxylase]]
+[[Category: Large Structures]]
-[[Category: Rudolph, M.]]
+[[Category: Rudolph M]]
-[[Category: Wittmann, J.]]
+[[Category: Wittmann J]]
-[[Category: Catalytic proficiency]]
-[[Category: Decarboxylase]]
-[[Category: Lyase]]
-[[Category: Tim barrel]]
-[[Category: Ump synthase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 14:57:51 2009''