2ppp: Difference between revisions

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[[Image:2ppp.png|left|200px]]


{{STRUCTURE_2ppp|  PDB=2ppp  |  SCENE=  }}
==Crystal structure of E60Q mutant of FKBP12==
 
<StructureSection load='2ppp' size='340' side='right'caption='[[2ppp]], [[Resolution|resolution]] 0.94&Aring;' scene=''>
===Crystal structure of E60Q mutant of FKBP12===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2ppp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PPP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PPP FirstGlance]. <br>
{{ABSTRACT_PUBMED_18704951}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.94&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ppp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ppp OCA], [https://pdbe.org/2ppp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ppp RCSB], [https://www.ebi.ac.uk/pdbsum/2ppp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ppp ProSAT]</span></td></tr>
==About this Structure==
</table>
[[2ppp]] is a 1 chain structure of [[Cyclophilin]] and [[FK506 binding protein]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PPP OCA].  
== Function ==
[https://www.uniprot.org/uniprot/FKB1A_HUMAN FKB1A_HUMAN] Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.<ref>PMID:9233797</ref> <ref>PMID:16720724</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pp/2ppp_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ppp ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Cyclophilin|Cyclophilin]]
*[[FKBP 3D structures|FKBP 3D structures]]
*[[FK506 binding protein|FK506 binding protein]]
== References ==
 
<references/>
==Reference==
__TOC__
<ref group="xtra">PMID:018704951</ref><references group="xtra"/>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Peptidylprolyl isomerase]]
[[Category: Large Structures]]
[[Category: Park, S.]]
[[Category: Park S]]
[[Category: Saven, J F.]]
[[Category: Saven JF]]
[[Category: Szep, S.]]
[[Category: Szep S]]
[[Category: VanDuyne, G D.]]
[[Category: VanDuyne GD]]
[[Category: High resolution protein structure]]
[[Category: Lyase]]

Latest revision as of 12:11, 21 February 2024

Crystal structure of E60Q mutant of FKBP12Crystal structure of E60Q mutant of FKBP12

Structural highlights

2ppp is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 0.94Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

FKB1A_HUMAN Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.[1] [2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Chen YG, Liu F, Massague J. Mechanism of TGFbeta receptor inhibition by FKBP12. EMBO J. 1997 Jul 1;16(13):3866-76. PMID:9233797 doi:10.1093/emboj/16.13.3866
  2. ↑ Yamaguchi T, Kurisaki A, Yamakawa N, Minakuchi K, Sugino H. FKBP12 functions as an adaptor of the Smad7-Smurf1 complex on activin type I receptor. J Mol Endocrinol. 2006 Jun;36(3):569-79. PMID:16720724 doi:10.1677/jme.1.01966

2ppp, resolution 0.94Å

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