2pa1: Difference between revisions

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-{{Seed}}
-[[Image:2pa1.png|left|200px]]
-<!--
+==Structure of the PDZ domain of human PDLIM2 bound to a C-terminal extension from human beta-tropomyosin==
-The line below this paragraph, containing "STRUCTURE_2pa1", creates the "Structure Box" on the page.
+<StructureSection load='2pa1' size='340' side='right'caption='[[2pa1]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2pa1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PA1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PA1 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-{{STRUCTURE_2pa1|  PDB=2pa1  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pa1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pa1 OCA], [https://pdbe.org/2pa1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pa1 RCSB], [https://www.ebi.ac.uk/pdbsum/2pa1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pa1 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PDLI2_HUMAN PDLI2_HUMAN] Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pa/2pa1_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pa1 ConSurf].
+<div style="clear:both"></div>
-===Structure of the PDZ domain of human PDLIM2 bound to a C-terminal extension from human beta-tropomyosin===
+==See Also==
+*[[PDZ and LIM domain protein|PDZ and LIM domain protein]]
+__TOC__
-==About this Structure==
+</StructureSection>
-PA1 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PA1 OCA].
 [[Category: Homo sapiens]]
-[[Category: Arrowsmith, C H.]]
+[[Category: Large Structures]]
-[[Category: Bunkoczi, G.]]
+[[Category: Arrowsmith CH]]
-[[Category: Burgess-Brown, N.]]
+[[Category: Bunkoczi G]]
-[[Category: Delft, F von.]]
+[[Category: Burgess-Brown N]]
-[[Category: Doyle, D A.]]
+[[Category: Doyle DA]]
-[[Category: Edwards, A.]]
+[[Category: Edwards A]]
-[[Category: Elkins, J.]]
+[[Category: Elkins J]]
-[[Category: Papagrigoriou, E.]]
+[[Category: Papagrigoriou E]]
-[[Category: Pike, A C.W.]]
+[[Category: Pike ACW]]
-[[Category: SGC, Structural Genomics Consortium.]]
+[[Category: Salah E]]
-[[Category: Salah, E.]]
+[[Category: Shrestha L]]
-[[Category: Shrestha, L.]]
+[[Category: Sundstrom M]]
-[[Category: Sundstrom, M.]]
+[[Category: Turnbull AP]]
-[[Category: Turnbull, A P.]]
+[[Category: Ugochukwu E]]
-[[Category: Ugochukwu, E.]]
+[[Category: Umeano C]]
-[[Category: Umeano, C.]]
+[[Category: Uppenberg J]]
-[[Category: Uppenberg, J.]]
+[[Category: Weigelt J]]
-[[Category: Weigelt, J.]]
+[[Category: Von Delft F]]
-[[Category: Pdz domain]]
-[[Category: Sgc]]
-[[Category: Structural genomic]]
-[[Category: Structural genomics consortium]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 19:55:27 2009''