2p54: Difference between revisions

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-[[Image:2p54.png|left|200px]]
-<!--
+==a crystal structure of PPAR alpha bound with SRC1 peptide and GW735==
-The line below this paragraph, containing "STRUCTURE_2p54", creates the "Structure Box" on the page.
+<StructureSection load='2p54' size='340' side='right'caption='[[2p54]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2p54]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P54 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P54 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.79&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=735:2-METHYL-2-(4-{[({4-METHYL-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOL-5-YL}CARBONYL)AMINO]METHYL}PHENOXY)PROPANOIC+ACID'>735</scene></td></tr>
-{{STRUCTURE_2p54|  PDB=2p54  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p54 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p54 OCA], [https://pdbe.org/2p54 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p54 RCSB], [https://www.ebi.ac.uk/pdbsum/2p54 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p54 ProSAT]</span></td></tr>
+</table>
-===a crystal structure of PPAR alpha bound with SRC1 peptide and GW735===
+== Function ==
+[https://www.uniprot.org/uniprot/PPARA_HUMAN PPARA_HUMAN] Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety (By similarity). Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2.<ref>PMID:7684926</ref> <ref>PMID:7629123</ref> <ref>PMID:9556573</ref> <ref>PMID:10195690</ref>
+== Evolutionary Conservation ==
-<!--
+[[Image:Consurf_key_small.gif|200px|right]]
-The line below this paragraph, {{ABSTRACT_PUBMED_17243659}}, adds the Publication Abstract to the page
+Check<jmol>
-(as it appears on PubMed at http://www.pubmed.gov), where 17243659 is the PubMed ID number.
+  <jmolCheckbox>
--->
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p5/2p54_consurf.spt"</scriptWhenChecked>
-{{ABSTRACT_PUBMED_17243659}}
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
-==About this Structure==
+  </jmolCheckbox>
-[[2p54]] is a 2 chain structure of [[Peroxisome Proliferator-Activated Receptors]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P54 OCA].
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2p54 ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Peroxisome Proliferator-Activated Receptors]]
+*[[Peroxisome proliferator-activated receptor 3D structures|Peroxisome proliferator-activated receptor 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:17243659</ref><references group="xtra"/>
+__TOC__
-[[Category: Histone acetyltransferase]]
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Lambert, M H.]]
+[[Category: Large Structures]]
-[[Category: Montana, V G.]]
+[[Category: Lambert MH]]
-[[Category: Pianetti, P M.]]
+[[Category: Montana VG]]
-[[Category: Sierra, M L.]]
+[[Category: Pianetti PM]]
-[[Category: Xu, H E.]]
+[[Category: Sierra ML]]
-[[Category: Xu, R X.]]
+[[Category: Xu HE]]
-[[Category: Ppar alpha gw735 src1 agonist hdlc]]
+[[Category: Xu RX]]
-[[Category: Transcription]]