2p4n: Difference between revisions

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-{{Seed}}
-[[Image:2p4n.png|left|200px]]
-<!--
+==Human Monomeric Kinesin (1BG2) and Bovine Tubulin (1JFF) Docked into the 9-Angstrom Cryo-EM Map of Nucleotide-Free Kinesin Complexed to the Microtubule==
-The line below this paragraph, containing "STRUCTURE_2p4n", creates the "Structure Box" on the page.
+<SX load='2p4n' size='340' side='right' viewer='molstar' caption='[[2p4n]], [[Resolution|resolution]] 9.00&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2p4n]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P4N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P4N FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 9&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TA1:TAXOL'>TA1</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-{{STRUCTURE_2p4n|  PDB=2p4n  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p4n OCA], [https://pdbe.org/2p4n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p4n RCSB], [https://www.ebi.ac.uk/pdbsum/2p4n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p4n ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/KINH_HUMAN KINH_HUMAN] Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes (By similarity).
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p4/2p4n_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2p4n ConSurf].
+<div style="clear:both"></div>
-===Human Monomeric Kinesin (1BG2) and Bovine Tubulin (1JFF) Docked into the 9-Angstrom Cryo-EM Map of Nucleotide-Free Kinesin Complexed to the Microtubule===
+==See Also==
+*[[Kinesin 3D Structures|Kinesin 3D Structures]]
+*[[Tubulin 3D Structures|Tubulin 3D Structures]]
-<!--
+__TOC__
-The line below this paragraph, {{ABSTRACT_PUBMED_17470637}}, adds the Publication Abstract to the page
+</SX>
-(as it appears on PubMed at http://www.pubmed.gov), where 17470637 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_17470637}}
-==About this Structure==
-P4N is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P4N OCA].
-==Reference==
-The beginning of kinesin's force-generating cycle visualized at 9-A resolution., Sindelar CV, Downing KH, J Cell Biol. 2007 May 7;177(3):377-85. Epub 2007 Apr 30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17470637 17470637]
 [[Category: Bos taurus]]
 [[Category: Homo sapiens]]
-[[Category: Protein complex]]
+[[Category: Large Structures]]
-[[Category: Downing, K H.]]
+[[Category: Downing KH]]
-[[Category: Sindelar, C V.]]
+[[Category: Sindelar CV]]
-[[Category: Atpase]]
-[[Category: Motor protein]]
-[[Category: Transport protein]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:16:23 2008''