2oz5: Difference between revisions

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-[[Image:2oz5.png|left|200px]]
-{{STRUCTURE_2oz5|  PDB=2oz5  |  SCENE=  }}
+==Crystal structure of Mycobacterium tuberculosis protein tyrosine phosphatase PtpB in complex with the specific inhibitor OMTS==
+<StructureSection load='2oz5' size='340' side='right'caption='[[2oz5]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-===Crystal structure of Mycobacterium tuberculosis protein tyrosine phosphatase PtpB in complex with the specific inhibitor OMTS===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2oz5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OZ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OZ5 FirstGlance]. <br>
-{{ABSTRACT_PUBMED_17437721}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7XY:{(3-CHLOROBENZYL)[(5-{[(3,3-DIPHENYLPROPYL)AMINO]SULFONYL}-2-THIENYL)METHYL]AMINO}(OXO)ACETIC+ACID'>7XY</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oz5 OCA], [https://pdbe.org/2oz5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oz5 RCSB], [https://www.ebi.ac.uk/pdbsum/2oz5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oz5 ProSAT]</span></td></tr>
-[[2oz5]] is a 2 chain structure of [[Tyrosine phosphatase]] with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OZ5 OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/P96830_MYCTO P96830_MYCTO]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oz/2oz5_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2oz5 ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Tyrosine phosphatase|Tyrosine phosphatase]]
+*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
+__TOC__
-==Reference==
+</StructureSection>
-<ref group="xtra">PMID:017437721</ref><references group="xtra"/>
+[[Category: Large Structures]]
-[[Category: Mycobacterium tuberculosis]]
+[[Category: Mycobacterium tuberculosis H37Rv]]
-[[Category: Alber, T.]]
+[[Category: Alber T]]
-[[Category: Gee, C L.]]
+[[Category: Gee CL]]
-[[Category: Grundner, C.]]
+[[Category: Grundner C]]
-[[Category: TBSGC, TB Structural Genomics Consortium.]]
-[[Category: Protein tyrosine phosphatase in complex with small molecule inhibitor]]
-[[Category: Structural genomic]]
-[[Category: Tb structural genomics consortium]]
-[[Category: Tbsgc]]
-[[Category: Unknown function]]