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==Crystal structure of CDP-bound protein MJ0056 from Methanococcus jannaschii, Pfam DUF120== | ==Crystal structure of CDP-bound protein MJ0056 from Methanococcus jannaschii, Pfam DUF120== | ||
<StructureSection load='2oyn' size='340' side='right' caption='[[2oyn]], [[Resolution|resolution]] 1.85Å' scene=''> | <StructureSection load='2oyn' size='340' side='right'caption='[[2oyn]], [[Resolution|resolution]] 1.85Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2oyn]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2oyn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii_DSM_2661 Methanocaldococcus jannaschii DSM 2661]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OYN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OYN FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85Å</td></tr> | ||
<tr><td class="sblockLbl"><b>[[ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CDP:CYTIDINE-5-DIPHOSPHATE'>CDP</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oyn OCA], [https://pdbe.org/2oyn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oyn RCSB], [https://www.ebi.ac.uk/pdbsum/2oyn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oyn ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/2oyn TOPSAN]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/RIFK_METJA RIFK_METJA] Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN). Can also utilize UTP as the phosphate donor, although less efficiently, and it is unclear if ATP and GTP can also serve as substrates (PubMed:18245297) or not (PubMed:18073108).<ref>PMID:18073108</ref> <ref>PMID:18245297</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oy/2oyn_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oy/2oyn_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2oyn ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Methanocaldococcus jannaschii | [[Category: Large Structures]] | ||
[[Category: Almo | [[Category: Methanocaldococcus jannaschii DSM 2661]] | ||
[[Category: Bain | [[Category: Almo SC]] | ||
[[Category: Bonanno | [[Category: Bain KT]] | ||
[[Category: Burley | [[Category: Bonanno JB]] | ||
[[Category: Dickey | [[Category: Burley SK]] | ||
[[Category: Lau | [[Category: Dickey M]] | ||
[[Category: Lau C]] | |||
[[Category: Romero | [[Category: Romero R]] | ||
[[Category: Sauder | [[Category: Sauder JM]] | ||
[[Category: Smith | [[Category: Smith D]] | ||
[[Category: Wasserman | [[Category: Wasserman S]] | ||
Latest revision as of 12:06, 21 February 2024
Crystal structure of CDP-bound protein MJ0056 from Methanococcus jannaschii, Pfam DUF120Crystal structure of CDP-bound protein MJ0056 from Methanococcus jannaschii, Pfam DUF120
Structural highlights
FunctionRIFK_METJA Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN). Can also utilize UTP as the phosphate donor, although less efficiently, and it is unclear if ATP and GTP can also serve as substrates (PubMed:18245297) or not (PubMed:18073108).[1] [2] Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. References
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