2oxx: Difference between revisions

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[[Image:2oxx.png|left|200px]]


{{STRUCTURE_2oxx|  PDB=2oxx  |  SCENE=  }}
==Protein kinase CK2 in complex with tetrabromobenzoimidazole derivatives K17, K22 and K32==
 
<StructureSection load='2oxx' size='340' side='right'caption='[[2oxx]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
===Protein kinase CK2 in complex with tetrabromobenzoimidazole derivatives K17, K22 and K32===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2oxx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Zea_mays Zea mays]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OXX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OXX FirstGlance]. <br>
{{ABSTRACT_PUBMED_17768728}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K22:4,5,6,7-TETRABROMO-1H,3H-BENZIMIDAZOL-2-THIONE'>K22</scene></td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oxx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oxx OCA], [https://pdbe.org/2oxx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oxx RCSB], [https://www.ebi.ac.uk/pdbsum/2oxx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oxx ProSAT]</span></td></tr>
[[2oxx]] is a 1 chain structure of [[Casein kinase]] with sequence from [http://en.wikipedia.org/wiki/Zea_mays Zea mays]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OXX OCA].  
</table>
== Function ==
[https://www.uniprot.org/uniprot/CSK2A_MAIZE CSK2A_MAIZE] Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha chain contains the catalytic site.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ox/2oxx_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2oxx ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Casein kinase|Casein kinase]]
*[[Casein kinase 3D structures|Casein kinase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:017768728</ref><references group="xtra"/>
[[Category: Large Structures]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Zea mays]]
[[Category: Zea mays]]
[[Category: Battistutta, R.]]
[[Category: Battistutta R]]
[[Category: Cendron, L.]]
[[Category: Cendron L]]
[[Category: Zanotti, G.]]
[[Category: Zanotti G]]
[[Category: Inhibitor]]
[[Category: Protein kinase ck2]]
[[Category: Tetrabromobenzoimidazole derivative]]
[[Category: Transferase]]

Latest revision as of 12:06, 21 February 2024

Protein kinase CK2 in complex with tetrabromobenzoimidazole derivatives K17, K22 and K32Protein kinase CK2 in complex with tetrabromobenzoimidazole derivatives K17, K22 and K32

Structural highlights

2oxx is a 1 chain structure with sequence from Zea mays. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.3Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CSK2A_MAIZE Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha chain contains the catalytic site.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2oxx, resolution 2.30Å

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