2ouv: Difference between revisions

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-{{Seed}}
-[[Image:2ouv.png|left|200px]]
-<!--
+==crystal structure of pde10a2 mutant of D564N==
-The line below this paragraph, containing "STRUCTURE_2ouv", creates the "Structure Box" on the page.
+<StructureSection load='2ouv' size='340' side='right'caption='[[2ouv]], [[Resolution|resolution]] 1.56&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2ouv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OUV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OUV FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.56&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-{{STRUCTURE_2ouv|  PDB=2ouv  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ouv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ouv OCA], [https://pdbe.org/2ouv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ouv RCSB], [https://www.ebi.ac.uk/pdbsum/2ouv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ouv ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ou/2ouv_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ouv ConSurf].
+<div style="clear:both"></div>
-===crystal structure of pde10a2 mutant of D564N===
+==See Also==
+*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
+== References ==
-<!--
+<references/>
-The line below this paragraph, {{ABSTRACT_PUBMED_17389385}}, adds the Publication Abstract to the page
+__TOC__
-(as it appears on PubMed at http://www.pubmed.gov), where 17389385 is the PubMed ID number.
+</StructureSection>
--->
-{{ABSTRACT_PUBMED_17389385}}
-==About this Structure==
-OUV is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OUV OCA].
-==Reference==
-<ref group="xtra">PMID:17389385</ref><references group="xtra"/>
-[[Category: 3',5'-cyclic-nucleotide phosphodiesterase]]
 [[Category: Homo sapiens]]
-[[Category: Hou, J.]]
+[[Category: Large Structures]]
-[[Category: Liu, Y D.]]
+[[Category: Hou J]]
-[[Category: Robinson, H.]]
+[[Category: Liu YD]]
-[[Category: Wang, H C.]]
+[[Category: Robinson H]]
-[[Category: Zheng, M Y.]]
+[[Category: Wang HC]]
-[[Category: Pde]]
+[[Category: Zheng MY]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 00:13:13 2009''