2iqh: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-{{Seed}}
-[[Image:2iqh.png|left|200px]]
-<!--
+==Influenza A virus nucleoprotein NP at 3.2A resolution==
-The line below this paragraph, containing "STRUCTURE_2iqh", creates the "Structure Box" on the page.
+<StructureSection load='2iqh' size='340' side='right'caption='[[2iqh]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2iqh]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Wilson-Smith/1933(H1N1)) Influenza A virus (A/Wilson-Smith/1933(H1N1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IQH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IQH FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iqh OCA], [https://pdbe.org/2iqh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iqh RCSB], [https://www.ebi.ac.uk/pdbsum/2iqh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iqh ProSAT]</span></td></tr>
-{{STRUCTURE_2iqh|  PDB=2iqh  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q1K9H2_I33A0 Q1K9H2_I33A0] Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals and is responsible of the active RNP import into the nucleus through the cellular importin alpha/beta pathway. Later in the infection, nucleus export of RNP are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that the nucleoprotein binds directly exportin-1 (XPO1) and plays an active role in RNP nuclear export. M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals. Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein. Dissociation of M1 from RNP unmask nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus (By similarity).[SAAS:SAAS002141_004_603280]
-===Influenza A virus nucleoprotein NP at 3.2A resolution===
+==See Also==
+*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
+__TOC__
-<!--
+</StructureSection>
-The line below this paragraph, {{ABSTRACT_PUBMED_17151603}}, adds the Publication Abstract to the page
+[[Category: Large Structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 17151603 is the PubMed ID number.
+[[Category: Tao YJ]]
--->
+[[Category: Ye Q]]
-{{ABSTRACT_PUBMED_17151603}}
-==About this Structure==
-IQH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IQH OCA].
-==Reference==
-The mechanism by which influenza A virus nucleoprotein forms oligomers and binds RNA., Ye Q, Krug RM, Tao YJ, Nature. 2006 Dec 21;444(7122):1078-82. Epub 2006 Dec 6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17151603 17151603]
-[[Category: Influenza a virus]]
-[[Category: Single protein]]
-[[Category: Tao, Y J.]]
-[[Category: Ye, Q.]]
-[[Category: Nl]]
-[[Category: Oligomerization]]
-[[Category: Polymerase binding]]
-[[Category: Rna binding]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:09:29 2008''