2iir: Difference between revisions

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[[Image:2iir.jpg|left|200px]]


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==Acetate kinase from a hypothermophile Thermotoga maritima==
The line below this paragraph, containing "STRUCTURE_2iir", creates the "Structure Box" on the page.
<StructureSection load='2iir' size='340' side='right'caption='[[2iir]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2iir]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IIR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IIR FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iir OCA], [https://pdbe.org/2iir PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iir RCSB], [https://www.ebi.ac.uk/pdbsum/2iir PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iir ProSAT]</span></td></tr>
{{STRUCTURE_2iir|  PDB=2iir  |  SCENE= }}
</table>
 
== Function ==
'''Acetate kinase from a hypothermophile Thermotoga maritima'''
[https://www.uniprot.org/uniprot/ACKA_THEMA ACKA_THEMA] Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction. Phosphorylates propionate (54%) in addition to acetate (100%). Uses GTP (100%), ITP (163%), UTP (56%), and CTP (21%) as phosphoryl donors in addition to ATP (100%).<ref>PMID:10074080</ref>
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
==About this Structure==
Check<jmol>
2IIR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IIR OCA].  
  <jmolCheckbox>
[[Category: Acetate kinase]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ii/2iir_consurf.spt"</scriptWhenChecked>
[[Category: Single protein]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: Thermotoga maritima]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: Hasson, M S.]]
  </jmolCheckbox>
[[Category: Mukhopadhyay, S.]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2iir ConSurf].
[[Category: Sanders, D A.]]
<div style="clear:both"></div>
[[Category: Acetate kinase]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Thermotoga maritima]]
[[Category: Thermotoga maritima]]
[[Category: Transferase]]
[[Category: Hasson MS]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 07:33:15 2008''
[[Category: Mukhopadhyay S]]
[[Category: Sanders DA]]

Latest revision as of 12:03, 21 February 2024

Acetate kinase from a hypothermophile Thermotoga maritimaAcetate kinase from a hypothermophile Thermotoga maritima

Structural highlights

2iir is a 10 chain structure with sequence from Thermotoga maritima. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3.3Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ACKA_THEMA Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction. Phosphorylates propionate (54%) in addition to acetate (100%). Uses GTP (100%), ITP (163%), UTP (56%), and CTP (21%) as phosphoryl donors in addition to ATP (100%).[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Bock AK, Glasemacher J, Schmidt R, Schonheit P. Purification and characterization of two extremely thermostable enzymes, phosphate acetyltransferase and acetate kinase, from the hyperthermophilic eubacterium Thermotoga maritima. J Bacteriol. 1999 Mar;181(6):1861-7. PMID:10074080

2iir, resolution 3.30Å

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