2ii4: Difference between revisions

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-[[Image:2ii4.png|left|200px]]
-{{STRUCTURE_2ii4|  PDB=2ii4  |  SCENE=  }}
+==Crystal structure of a cubic core of the dihydrolipoamide acyltransferase (E2b) component in the branched-chain alpha-ketoacid dehydrogenase complex (BCKDC), Coenzyme A-bound form==
+<StructureSection load='2ii4' size='340' side='right'caption='[[2ii4]], [[Resolution|resolution]] 2.59&Aring;' scene=''>
-===Crystal structure of a cubic core of the dihydrolipoamide acyltransferase (E2b) component in the branched-chain alpha-ketoacid dehydrogenase complex (BCKDC), Coenzyme A-bound form===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2ii4]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2II4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2II4 FirstGlance]. <br>
-{{ABSTRACT_PUBMED_17124494}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.59&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ii4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ii4 OCA], [https://pdbe.org/2ii4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ii4 RCSB], [https://www.ebi.ac.uk/pdbsum/2ii4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ii4 ProSAT]</span></td></tr>
-[[2ii4]] is a 8 chain structure of [[Dihydrolipoamide dehydrogenase]] with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2II4 OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ODB2_BOVIN ODB2_BOVIN] The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ii/2ii4_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ii4 ConSurf].
+<div style="clear:both"></div>
 ==See Also==
 *[[Dihydrolipoamide dehydrogenase|Dihydrolipoamide dehydrogenase]]
+__TOC__
-==Reference==
+</StructureSection>
-<ref group="xtra">PMID:017124494</ref><references group="xtra"/>
 [[Category: Bos taurus]]
-[[Category: Brautigam, C A.]]
+[[Category: Large Structures]]
-[[Category: Chuang, D T.]]
+[[Category: Brautigam CA]]
-[[Category: Chuang, J L.]]
+[[Category: Chuang DT]]
-[[Category: Custorio, M.]]
+[[Category: Chuang JL]]
-[[Category: Kato, M.]]
+[[Category: Custorio M]]
-[[Category: Wynn, R M.]]
+[[Category: Kato M]]
-[[Category: Coa-bound form]]
+[[Category: Wynn RM]]
-[[Category: Cubic core]]
-[[Category: Homo trimer]]
-[[Category: Transferase]]