2i4w: Difference between revisions

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-[[Image:2i4w.png|left|200px]]
-{{STRUCTURE_2i4w|  PDB=2i4w  |  SCENE=  }}
+==HIV-1 protease WT with GS-8374==
+<StructureSection load='2i4w' size='340' side='right'caption='[[2i4w]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
-===HIV-1 protease WT with GS-8374===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2i4w]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I4W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I4W FirstGlance]. <br>
-{{ABSTRACT_PUBMED_16979654}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KGQ:DIETHYL+({4-[(2S,3R)-2-({[(3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YLOXY]CARBONYL}AMINO)-3-HYDROXY-4-{ISOBUTYL[(4-METHOXYPHENYL)SULFONYL]AMINO}BUTYL]PHENOXY}METHYL)PHOSPHONATE'>KGQ</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i4w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i4w OCA], [https://pdbe.org/2i4w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i4w RCSB], [https://www.ebi.ac.uk/pdbsum/2i4w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i4w ProSAT]</span></td></tr>
-[[2i4w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I4W OCA].
+</table>
+== Function ==
-==Reference==
+[https://www.uniprot.org/uniprot/O92139_9HIV1 O92139_9HIV1]
-<ref group="xtra">PMID:016979654</ref><references group="xtra"/>
+== Evolutionary Conservation ==
-[[Category: HIV-1 retropepsin]]
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i4/2i4w_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2i4w ConSurf].
+<div style="clear:both"></div>
+__TOC__
+</StructureSection>
 [[Category: Human immunodeficiency virus 1]]
-[[Category: Hatada, M.]]
+[[Category: Large Structures]]
-[[Category: Hiv-1 protease inhibitor]]
+[[Category: Hatada M]]
-[[Category: Hydrolase]]