3o63: Difference between revisions

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==Crystal Structure of Thiamin Phosphate Synthase from Mycobacterium tuberculosis==
==Crystal Structure of Thiamin Phosphate Synthase from Mycobacterium tuberculosis==
<StructureSection load='3o63' size='340' side='right' caption='[[3o63]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
<StructureSection load='3o63' size='340' side='right'caption='[[3o63]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3o63]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O63 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3O63 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3o63]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O63 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O63 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MT0427, MTCY22G10.11c, Rv0414c, thiE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thiamine-phosphate_diphosphorylase Thiamine-phosphate diphosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.3 2.5.1.3] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o63 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o63 OCA], [https://pdbe.org/3o63 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o63 RCSB], [https://www.ebi.ac.uk/pdbsum/3o63 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o63 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3o63 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o63 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3o63 RCSB], [http://www.ebi.ac.uk/pdbsum/3o63 PDBsum]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/THIE_MYCTU THIE_MYCTU]] Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).<ref>PMID:21818324</ref>
[https://www.uniprot.org/uniprot/THIE_MYCTU THIE_MYCTU] Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).<ref>PMID:21818324</ref>  
 
==See Also==
*[[Thiamin phosphate synthase|Thiamin phosphate synthase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Thiamine-phosphate diphosphorylase]]
[[Category: Begley TP]]
[[Category: Begley, T P]]
[[Category: Ealick SE]]
[[Category: Ealick, S E]]
[[Category: Guida WC]]
[[Category: Guida, W C]]
[[Category: Ishida K]]
[[Category: Ishida, K]]
[[Category: McCulloch KM]]
[[Category: McCulloch, K M]]
[[Category: Ramamoorthy D]]
[[Category: Ramamoorthy, D]]
[[Category: Thiamin biosynthesis]]
[[Category: Tim barrel]]
[[Category: Transferase]]

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