3nwb: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:3nwb.png|left|200px]]
-<!--
+==Rat COMT in complex with a fluorinated desoxyribose-containing bisubstrate inhibitor avoids hydroxyl group==
-The line below this paragraph, containing "STRUCTURE_3nwb", creates the "Structure Box" on the page.
+<StructureSection load='3nwb' size='340' side='right'caption='[[3nwb]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3nwb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NWB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NWB FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=659:N-[(E)-3-[(2R,3R,4S,5R)-3-FLUORO-4-HYDROXY-5-[6-(METHYLAMINO)PURIN-9-YL]OXOLAN-2-YL]PROP-2-ENYL]-5-(4-FLUOROPHENYL)-2,3-DIHYDROXY-BENZAMIDE'>659</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-{{STRUCTURE_3nwb|  PDB=3nwb  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nwb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nwb OCA], [https://pdbe.org/3nwb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nwb RCSB], [https://www.ebi.ac.uk/pdbsum/3nwb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nwb ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/COMT_RAT COMT_RAT] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
-===Rat COMT in complex with a fluorinated desoxyribose-containing bisubstrate inhibitor avoids hydroxyl group===
+==See Also==
+*[[Catechol O-methyltransferase 3D structures|Catechol O-methyltransferase 3D structures]]
+__TOC__
-==About this Structure==
+</StructureSection>
-[[3nwb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NWB OCA].
+[[Category: Large Structures]]
-[[Category: Catechol O-methyltransferase]]
 [[Category: Rattus norvegicus]]
-[[Category: Benz, J.]]
+[[Category: Benz J]]
-[[Category: Ehler, A.]]
+[[Category: Ehler A]]
-[[Category: Rudolph, M G.]]
+[[Category: Rudolph MG]]
-[[Category: Schlatter, D.]]
+[[Category: Schlatter D]]
-[[Category: Stihle, M.]]
+[[Category: Stihle M]]
-[[Category: Alternative initiation]]
-[[Category: Catecholamine metabolism]]
-[[Category: Cell membrane]]
-[[Category: Magnesium]]
-[[Category: Membrane]]
-[[Category: Metal-binding]]
-[[Category: Methyltransferase]]
-[[Category: Neurotransmitter degradation]]
-[[Category: Phosphoprotein]]
-[[Category: S-adenosyl-l-methionine]]
-[[Category: Signal-anchor]]
-[[Category: Transferase-transferase inhibitor complex]]
-[[Category: Transmembrane]]