3n57: Difference between revisions

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-[[Image:3n57.png|left|200px]]
-{{STRUCTURE_3n57|  PDB=3n57  |  SCENE=  }}
+==Crystal Structure of human Insulin-degrading enzyme (IDE) in complex with human atrial natriuretic peptide (ANP)==
+<StructureSection load='3n57' size='340' side='right'caption='[[3n57]], [[Resolution|resolution]] 3.03&Aring;' scene=''>
-===Crystal Structure of human Insulin-degrading enzyme (IDE) in complex with human atrial natriuretic peptide (ANP)===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3n57]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N57 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N57 FirstGlance]. <br>
-{{ABSTRACT_PUBMED_021098034}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.03&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n57 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n57 OCA], [https://pdbe.org/3n57 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n57 RCSB], [https://www.ebi.ac.uk/pdbsum/3n57 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n57 ProSAT]</span></td></tr>
-[[3n57]] is a 4 chain structure of [[Insulin-Degrading Enzyme]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N57 OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref>
 ==See Also==
-*[[Insulin-Degrading Enzyme|Insulin-Degrading Enzyme]]
+*[[Insulin-degrading enzyme 3D structures|Insulin-degrading enzyme 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:021098034</ref><references group="xtra"/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Insulysin]]
+[[Category: Large Structures]]
-[[Category: Funke, T.]]
+[[Category: Funke T]]
-[[Category: Guo, Q.]]
+[[Category: Guo Q]]
-[[Category: Tang, W J.]]
+[[Category: Tang W-J]]
-[[Category: A-beta degrading enzyme]]
-[[Category: Cardiac]]
-[[Category: Cardiovascular regulation]]
-[[Category: Cryptidase]]
-[[Category: Diabetes mellitus]]
-[[Category: Disease mutation]]
-[[Category: Disulfide bond]]
-[[Category: Hormone]]
-[[Category: Human insulin-degradng enzyme]]
-[[Category: Hydrolase]]
-[[Category: Hydrolase-hormone complex]]
-[[Category: Insulin]]
-[[Category: Insulinase]]
-[[Category: Insulysin]]
-[[Category: Metal-binding]]
-[[Category: Metalloprotease]]
-[[Category: Natriuretic factor]]
-[[Category: Natriuretic peptide]]
-[[Category: Protease]]
-[[Category: Secreted]]