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==Crystal structure of Tm1821, the 8-oxoguanine DNA glycosylase of Thermotoga maritima==
==Crystal structure of Tm1821, the 8-oxoguanine DNA glycosylase of Thermotoga maritima==
<StructureSection load='3n0u' size='340' side='right' caption='[[3n0u]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
<StructureSection load='3n0u' size='340' side='right'caption='[[3n0u]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3n0u]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N0U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3N0U FirstGlance]. <br>
<table><tr><td colspan='2'>[[3n0u]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N0U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N0U FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ogg, Tm1821, TM_1821 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 Thermotoga maritima])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n0u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n0u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3n0u RCSB], [http://www.ebi.ac.uk/pdbsum/3n0u PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n0u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n0u OCA], [https://pdbe.org/3n0u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n0u RCSB], [https://www.ebi.ac.uk/pdbsum/3n0u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n0u ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/OGG1_THEMA OGG1_THEMA]] Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites) (By similarity).  
[https://www.uniprot.org/uniprot/OGG1_THEMA OGG1_THEMA] Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites) (By similarity).


==See Also==
==See Also==
*[[DNA glycosylase|DNA glycosylase]]
*[[DNA glycosylase 3D structures|DNA glycosylase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Thermotoga maritima]]
[[Category: Thermotoga maritima]]
[[Category: Cooper, D R]]
[[Category: Cooper DR]]
[[Category: Derewenda, Z S]]
[[Category: Derewenda ZS]]
[[Category: ISFI, Integrated Center for Structure and Function Innovation]]
[[Category: Roy A]]
[[Category: Roy, A]]
[[Category: 8-oxoguanine]]
[[Category: Base excision repair]]
[[Category: Dna repair]]
[[Category: Hydrolase]]
[[Category: Integrated center for structure and function innovation]]
[[Category: Isfi]]
[[Category: Lyase]]
[[Category: PSI, Protein structure initiative]]
[[Category: Structural genomic]]

Latest revision as of 12:58, 14 February 2024

Crystal structure of Tm1821, the 8-oxoguanine DNA glycosylase of Thermotoga maritimaCrystal structure of Tm1821, the 8-oxoguanine DNA glycosylase of Thermotoga maritima

Structural highlights

3n0u is a 3 chain structure with sequence from Thermotoga maritima. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.5Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

OGG1_THEMA Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites) (By similarity).

See Also

3n0u, resolution 1.50Å

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