2hs2: Difference between revisions

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-[[Image:2hs2.png|left|200px]]
-{{STRUCTURE_2hs2|  PDB=2hs2  |  SCENE=  }}
+==Crystal structure of M46L mutant of HIV-1 protease complexed with TMC114 (darunavir)==
+<StructureSection load='2hs2' size='340' side='right'caption='[[2hs2]], [[Resolution|resolution]] 1.22&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2hs2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HS2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HS2 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.22&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=017:(3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE'>017</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hs2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hs2 OCA], [https://pdbe.org/2hs2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hs2 RCSB], [https://www.ebi.ac.uk/pdbsum/2hs2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hs2 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q7SSI0_9HIV1 Q7SSI0_9HIV1]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hs/2hs2_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hs2 ConSurf].
+<div style="clear:both"></div>
-===Crystal structure of M46L mutant of HIV-1 protease complexed with TMC114 (darunavir)===
+==See Also==
+*[[Immunodeficiency virus protease 3D structures|Immunodeficiency virus protease 3D structures]]
-{{ABSTRACT_PUBMED_16962136}}
+__TOC__
+</StructureSection>
-==About this Structure==
-[[2hs2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HS2 OCA].
-==Reference==
-<ref group="xtra">PMID:016962136</ref><references group="xtra"/>
-[[Category: HIV-1 retropepsin]]
 [[Category: Human immunodeficiency virus 1]]
-[[Category: Kovalevsky, A Y.]]
+[[Category: Large Structures]]
-[[Category: Liu, F.]]
+[[Category: Kovalevsky AY]]
-[[Category: Weber, I T.]]
+[[Category: Liu F]]
-[[Category: Aspartic protease active site surface binding site]]
+[[Category: Weber IT]]
-[[Category: Hydrolase]]