2hqg: Difference between revisions

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[[Image:2hqg.png|left|200px]]


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==Conformation of the AcrB Multidrug Efflux Pump in Mutants of the Putative Proton Relay Pathway==
The line below this paragraph, containing "STRUCTURE_2hqg", creates the "Structure Box" on the page.
<StructureSection load='2hqg' size='340' side='right'caption='[[2hqg]], [[Resolution|resolution]] 3.38&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2hqg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HQG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HQG FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.38&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hqg OCA], [https://pdbe.org/2hqg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hqg RCSB], [https://www.ebi.ac.uk/pdbsum/2hqg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hqg ProSAT]</span></td></tr>
{{STRUCTURE_2hqg|  PDB=2hqg  |  SCENE=  }}
</table>
 
== Function ==
===Conformation of the AcrB Multidrug Efflux Pump in Mutants of the Putative Proton Relay Pathway===
[https://www.uniprot.org/uniprot/ACRB_ECOLI ACRB_ECOLI] AcrAB is a drug efflux protein with a broad substrate specificity.<ref>PMID:16915237</ref> <ref>PMID:16946072</ref> <ref>PMID:17194213</ref>
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
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    <text>to colour the structure by Evolutionary Conservation</text>
 
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==About this Structure==
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hqg ConSurf].
2HQG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HQG OCA].  
<div style="clear:both"></div>
 
== References ==
==Reference==
<references/>
Conformation of the AcrB multidrug efflux pump in mutants of the putative proton relay pathway., Su CC, Li M, Gu R, Takatsuka Y, McDermott G, Nikaido H, Yu EW, J Bacteriol. 2006 Oct;188(20):7290-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17015668 17015668]
__TOC__
[[Category: Escherichia coli]]
</StructureSection>
[[Category: Single protein]]
[[Category: Escherichia coli K-12]]
[[Category: Gu, R.]]
[[Category: Large Structures]]
[[Category: Li, M.]]
[[Category: Gu R]]
[[Category: McDermott, G.]]
[[Category: Li M]]
[[Category: Nikaido, H.]]
[[Category: McDermott G]]
[[Category: Su, C C.]]
[[Category: Nikaido H]]
[[Category: Takatsuka, Y.]]
[[Category: Su C-C]]
[[Category: Yu, E W.]]
[[Category: Takatsuka Y]]
[[Category: Membrane protein]]
[[Category: Yu EW]]
[[Category: Multidrug efflux pump]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:50:45 2008''

Latest revision as of 12:34, 14 February 2024

Conformation of the AcrB Multidrug Efflux Pump in Mutants of the Putative Proton Relay PathwayConformation of the AcrB Multidrug Efflux Pump in Mutants of the Putative Proton Relay Pathway

Structural highlights

2hqg is a 1 chain structure with sequence from Escherichia coli K-12. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3.38Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ACRB_ECOLI AcrAB is a drug efflux protein with a broad substrate specificity.[1] [2] [3]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Murakami S, Nakashima R, Yamashita E, Matsumoto T, Yamaguchi A. Crystal structures of a multidrug transporter reveal a functionally rotating mechanism. Nature. 2006 Sep 14;443(7108):173-9. Epub 2006 Aug 16. PMID:16915237 doi:10.1038/nature05076
  2. ↑ Seeger MA, Schiefner A, Eicher T, Verrey F, Diederichs K, Pos KM. Structural asymmetry of AcrB trimer suggests a peristaltic pump mechanism. Science. 2006 Sep 1;313(5791):1295-8. PMID:16946072 doi:313/5791/1295
  3. ↑ Sennhauser G, Amstutz P, Briand C, Storchenegger O, Grutter MG. Drug export pathway of multidrug exporter AcrB revealed by DARPin inhibitors. PLoS Biol. 2007 Jan;5(1):e7. PMID:17194213 doi:10.1371/journal.pbio.0050007

2hqg, resolution 3.38Å

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