2hqg: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older edit
m Protected "2hqg" [edit=sysop:move=sysop]
No edit summary
 
(5 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:2hqg.png|left|200px]]


{{STRUCTURE_2hqg|  PDB=2hqg  |  SCENE=  }}
==Conformation of the AcrB Multidrug Efflux Pump in Mutants of the Putative Proton Relay Pathway==
 
<StructureSection load='2hqg' size='340' side='right'caption='[[2hqg]], [[Resolution|resolution]] 3.38&Aring;' scene=''>
===Conformation of the AcrB Multidrug Efflux Pump in Mutants of the Putative Proton Relay Pathway===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2hqg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HQG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HQG FirstGlance]. <br>
{{ABSTRACT_PUBMED_17015668}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.38&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hqg OCA], [https://pdbe.org/2hqg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hqg RCSB], [https://www.ebi.ac.uk/pdbsum/2hqg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hqg ProSAT]</span></td></tr>
==About this Structure==
</table>
[[2hqg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HQG OCA].  
== Function ==
 
[https://www.uniprot.org/uniprot/ACRB_ECOLI ACRB_ECOLI] AcrAB is a drug efflux protein with a broad substrate specificity.<ref>PMID:16915237</ref> <ref>PMID:16946072</ref> <ref>PMID:17194213</ref>  
==Reference==
== Evolutionary Conservation ==
<ref group="xtra">PMID:017015668</ref><references group="xtra"/>
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: Escherichia coli k-12]]
Check<jmol>
[[Category: Gu, R.]]
  <jmolCheckbox>
[[Category: Li, M.]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hq/2hqg_consurf.spt"</scriptWhenChecked>
[[Category: McDermott, G.]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: Nikaido, H.]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: Su, C C.]]
  </jmolCheckbox>
[[Category: Takatsuka, Y.]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hqg ConSurf].
[[Category: Yu, E W.]]
<div style="clear:both"></div>
[[Category: Membrane protein]]
== References ==
[[Category: Multidrug efflux pump]]
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia coli K-12]]
[[Category: Large Structures]]
[[Category: Gu R]]
[[Category: Li M]]
[[Category: McDermott G]]
[[Category: Nikaido H]]
[[Category: Su C-C]]
[[Category: Takatsuka Y]]
[[Category: Yu EW]]

Latest revision as of 12:34, 14 February 2024

Conformation of the AcrB Multidrug Efflux Pump in Mutants of the Putative Proton Relay PathwayConformation of the AcrB Multidrug Efflux Pump in Mutants of the Putative Proton Relay Pathway

Structural highlights

2hqg is a 1 chain structure with sequence from Escherichia coli K-12. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3.38Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ACRB_ECOLI AcrAB is a drug efflux protein with a broad substrate specificity.[1] [2] [3]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Murakami S, Nakashima R, Yamashita E, Matsumoto T, Yamaguchi A. Crystal structures of a multidrug transporter reveal a functionally rotating mechanism. Nature. 2006 Sep 14;443(7108):173-9. Epub 2006 Aug 16. PMID:16915237 doi:10.1038/nature05076
  2. ↑ Seeger MA, Schiefner A, Eicher T, Verrey F, Diederichs K, Pos KM. Structural asymmetry of AcrB trimer suggests a peristaltic pump mechanism. Science. 2006 Sep 1;313(5791):1295-8. PMID:16946072 doi:313/5791/1295
  3. ↑ Sennhauser G, Amstutz P, Briand C, Storchenegger O, Grutter MG. Drug export pathway of multidrug exporter AcrB revealed by DARPin inhibitors. PLoS Biol. 2007 Jan;5(1):e7. PMID:17194213 doi:10.1371/journal.pbio.0050007

2hqg, resolution 3.38Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=2hqg&oldid=4059096"