2h14: Difference between revisions

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-[[Image:2h14.png|left|200px]]
-{{STRUCTURE_2h14|  PDB=2h14  |  SCENE=  }}
+==Crystal of WDR5 (apo-form)==
+<StructureSection load='2h14' size='340' side='right'caption='[[2h14]], [[Resolution|resolution]] 1.48&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2h14]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H14 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2H14 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.48&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2h14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h14 OCA], [https://pdbe.org/2h14 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2h14 RCSB], [https://www.ebi.ac.uk/pdbsum/2h14 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2h14 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h1/2h14_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2h14 ConSurf].
+<div style="clear:both"></div>
-===Crystal of WDR5 (apo-form)===
+==See Also==
+*[[WD-repeat protein 3D structures|WD-repeat protein 3D structures]]
-{{ABSTRACT_PUBMED_16829960}}
+== References ==
+<references/>
-==About this Structure==
+__TOC__
-[[2h14]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H14 OCA].
+</StructureSection>
-==Reference==
-<ref group="xtra">PMID:016829960</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Collazo, E.]]
+[[Category: Large Structures]]
-[[Category: Couture, J F.]]
+[[Category: Collazo E]]
-[[Category: Trievel, R C.]]
+[[Category: Couture JF]]
-[[Category: Beta-propeller]]
+[[Category: Trievel RC]]
-[[Category: Histone]]
-[[Category: Mll]]
-[[Category: Transcription]]
-[[Category: Wd-40 repeat]]