2gsr: Difference between revisions

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[[Image:2gsr.png|left|200px]]


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==Structure of porcine class pi glutathione s-transferase==
The line below this paragraph, containing "STRUCTURE_2gsr", creates the "Structure Box" on the page.
<StructureSection load='2gsr' size='340' side='right'caption='[[2gsr]], [[Resolution|resolution]] 2.11&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2gsr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1gsr 1gsr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GSR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GSR FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.11&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTS:GLUTATHIONE+SULFONIC+ACID'>GTS</scene></td></tr>
{{STRUCTURE_2gsr| PDB=2gsr |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gsr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gsr OCA], [https://pdbe.org/2gsr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gsr RCSB], [https://www.ebi.ac.uk/pdbsum/2gsr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gsr ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GSTP1_PIG GSTP1_PIG] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gs/2gsr_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gsr ConSurf].
<div style="clear:both"></div>


===Structure of porcine class pi glutathione s-transferase===
==See Also==
 
*[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]]
 
__TOC__
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</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_7932743}}, adds the Publication Abstract to the page
[[Category: Large Structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 7932743 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7932743}}
 
==About this Structure==
[[2gsr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1gsr 1gsr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GSR OCA].
 
==Reference==
<ref group="xtra">PMID:007932743</ref><references group="xtra"/>
[[Category: Glutathione transferase]]
[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
[[Category: Dirr, H W.]]
[[Category: Dirr HW]]
[[Category: Huber, R.]]
[[Category: Huber R]]
[[Category: Reinemer, P.]]
[[Category: Reinemer P]]
[[Category: Transferase-transferase inhibitor complex]]

Latest revision as of 12:29, 14 February 2024

Structure of porcine class pi glutathione s-transferaseStructure of porcine class pi glutathione s-transferase

Structural highlights

2gsr is a 2 chain structure with sequence from Sus scrofa. This structure supersedes the now removed PDB entry 1gsr. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.11Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GSTP1_PIG Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2gsr, resolution 2.11Å

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OCA
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