2gfv: Difference between revisions

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-{{Seed}}
-[[Image:2gfv.png|left|200px]]
-<!--
+==Structure of E. coli FabF (KASII) C163Q mutant==
-The line below this paragraph, containing "STRUCTURE_2gfv", creates the "Structure Box" on the page.
+<StructureSection load='2gfv' size='340' side='right'caption='[[2gfv]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2gfv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GFV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GFV FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.29&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gfv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gfv OCA], [https://pdbe.org/2gfv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gfv RCSB], [https://www.ebi.ac.uk/pdbsum/2gfv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gfv ProSAT]</span></td></tr>
-{{STRUCTURE_2gfv|  PDB=2gfv  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/FABF_ECOLI FABF_ECOLI] Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthesis.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gf/2gfv_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gfv ConSurf].
+<div style="clear:both"></div>
-===Structure of E. coli FabF (KASII) C163Q mutant===
+==See Also==
+*[[Acyl carrier protein synthase 3D structures|Acyl carrier protein synthase 3D structures]]
+__TOC__
-<!--
+</StructureSection>
-The line below this paragraph, {{ABSTRACT_PUBMED_16710421}}, adds the Publication Abstract to the page
-(as it appears on PubMed at http://www.pubmed.gov), where 16710421 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_16710421}}
-==About this Structure==
-GFV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GFV OCA].
-==Reference==
-Platensimycin is a selective FabF inhibitor with potent antibiotic properties., Wang J, Soisson SM, Young K, Shoop W, Kodali S, Galgoci A, Painter R, Parthasarathy G, Tang YS, Cummings R, Ha S, Dorso K, Motyl M, Jayasuriya H, Ondeyka J, Herath K, Zhang C, Hernandez L, Allocco J, Basilio A, Tormo JR, Genilloud O, Vicente F, Pelaez F, Colwell L, Lee SH, Michael B, Felcetto T, Gill C, Silver LL, Hermes JD, Bartizal K, Barrett J, Schmatz D, Becker JW, Cully D, Singh SB, Nature. 2006 May 18;441(7091):358-61. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16710421 16710421]
-[[Category: Beta-ketoacyl-acyl-carrier-protein synthase I]]
 [[Category: Escherichia coli]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Parthasarathy, G]]
+[[Category: Parthasarathy G]]
-[[Category: Soisson, S M.]]
+[[Category: Soisson SM]]
-[[Category: Acyl-enzyme intermediate]]
-[[Category: Fabf]]
-[[Category: Kasii]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 22:45:12 2008''