2g9c: Difference between revisions

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-[[Image:2g9c.gif|left|200px]]
- {{Structure
+==Modified pyrimidines Specifically bind the purine riboswitch==
-|PDB= 2g9c |SIZE=350|CAPTION= <scene name='initialview01'>2g9c</scene>, resolution 1.70&Aring;
+<StructureSection load='2g9c' size='340' side='right'caption='[[2g9c]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND= <scene name='pdbligand=3AY:PYRIMIDINE-2,4,6-TRIAMINE'>3AY</scene>, <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE+ION'>NCO</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
+<table><tr><td colspan='2'>[[2g9c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G9C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G9C FirstGlance]. <br>
-|ACTIVITY=
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
-|GENE=
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3AY:PYRIMIDINE-2,4,6-TRIAMINE'>3AY</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene></td></tr>
-|DOMAIN=
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g9c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g9c OCA], [https://pdbe.org/2g9c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g9c RCSB], [https://www.ebi.ac.uk/pdbsum/2g9c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g9c ProSAT]</span></td></tr>
-|RELATEDENTRY=
+</table>
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g9c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g9c OCA], [http://www.ebi.ac.uk/pdbsum/2g9c PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2g9c RCSB]</span>
-}}
-'''Modified pyrimidines Specifically bind the purine riboswitch'''
+==See Also==
+*[[Riboswitch 3D structures|Riboswitch 3D structures]]
+__TOC__
-==Overview==
+</StructureSection>
-The purine riboswitch is a genetic regulatory element found in the 5'-untranslated regions of Gram-positive bacteria that regulates expression of the mRNA specifically in response to either guanine or adenine. We report that the adenine-responsive RNA element is also capable of specifically recognizing pyrimidine compounds bearing modifications at the 6- or 5,6-positions in a fashion similar to that of purine compounds. Using isothermal titration calorimetry and X-ray crystallography, the binding of these compounds is characterized.
+[[Category: Bacillus subtilis]]
+[[Category: Large Structures]]
-==About this Structure==
+[[Category: Batey RT]]
-G9C is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G9C OCA].
+[[Category: Gilbert SD]]
+[[Category: Mediatore SJ]]
-==Reference==
-Modified pyrimidines specifically bind the purine riboswitch., Gilbert SD, Mediatore SJ, Batey RT, J Am Chem Soc. 2006 Nov 8;128(44):14214-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17076468 17076468]
-[[Category: Protein complex]]
-[[Category: Batey, R T.]]
-[[Category: Gilbert, S D.]]
-[[Category: Mediatore, S J.]]
-[[Category: mrna]]
-[[Category: riboswitch]]
-[[Category: rna-ligand complex]]
-[[Category: triaminopyrimidine]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:13:32 2008''