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==Modified pyrimidines Specifically bind the purine riboswitch==
==Modified pyrimidines Specifically bind the purine riboswitch==
<StructureSection load='2g9c' size='340' side='right' caption='[[2g9c]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='2g9c' size='340' side='right'caption='[[2g9c]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2g9c]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G9C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2G9C FirstGlance]. <br>
<table><tr><td colspan='2'>[[2g9c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G9C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G9C FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3AY:PYRIMIDINE-2,4,6-TRIAMINE'>3AY</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g9c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g9c OCA], [http://pdbe.org/2g9c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2g9c RCSB], [http://www.ebi.ac.uk/pdbsum/2g9c PDBsum]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3AY:PYRIMIDINE-2,4,6-TRIAMINE'>3AY</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g9c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g9c OCA], [https://pdbe.org/2g9c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g9c RCSB], [https://www.ebi.ac.uk/pdbsum/2g9c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g9c ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The purine riboswitch is a genetic regulatory element found in the 5'-untranslated regions of Gram-positive bacteria that regulates expression of the mRNA specifically in response to either guanine or adenine. We report that the adenine-responsive RNA element is also capable of specifically recognizing pyrimidine compounds bearing modifications at the 6- or 5,6-positions in a fashion similar to that of purine compounds. Using isothermal titration calorimetry and X-ray crystallography, the binding of these compounds is characterized.
Modified pyrimidines specifically bind the purine riboswitch.,Gilbert SD, Mediatore SJ, Batey RT J Am Chem Soc. 2006 Nov 8;128(44):14214-5. PMID:17076468<ref>PMID:17076468</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2g9c" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Riboswitch|Riboswitch]]
*[[Riboswitch 3D structures|Riboswitch 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Batey, R T]]
[[Category: Bacillus subtilis]]
[[Category: Gilbert, S D]]
[[Category: Large Structures]]
[[Category: Mediatore, S J]]
[[Category: Batey RT]]
[[Category: Mrna]]
[[Category: Gilbert SD]]
[[Category: Riboswitch]]
[[Category: Mediatore SJ]]
[[Category: Rna]]
[[Category: Rna-ligand complex]]
[[Category: Triaminopyrimidine]]

Latest revision as of 12:26, 14 February 2024

Modified pyrimidines Specifically bind the purine riboswitchModified pyrimidines Specifically bind the purine riboswitch

Structural highlights

2g9c is a 1 chain structure with sequence from Bacillus subtilis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.7Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

See Also

2g9c, resolution 1.70Å

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