2g8d: Difference between revisions

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-{{Seed}}
-[[Image:2g8d.png|left|200px]]
-<!--
+==Lactobacillus casei thymidylate synthase Y261W-dUMP complex==
-The line below this paragraph, containing "STRUCTURE_2g8d", creates the "Structure Box" on the page.
+<StructureSection load='2g8d' size='340' side='right'caption='[[2g8d]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2g8d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lacticaseibacillus_casei Lacticaseibacillus casei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G8D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G8D FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
-{{STRUCTURE_2g8d|  PDB=2g8d  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g8d OCA], [https://pdbe.org/2g8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g8d RCSB], [https://www.ebi.ac.uk/pdbsum/2g8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g8d ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/TYSY_LACCA TYSY_LACCA] Provides the sole de novo source of dTMP for DNA biosynthesis.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g8/2g8d_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2g8d ConSurf].
+<div style="clear:both"></div>
-===Lactobacillus casei thymidylate synthase Y261W-dUMP complex===
+==See Also==
+*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]]
+__TOC__
-<!--
+</StructureSection>
-The line below this paragraph, {{ABSTRACT_PUBMED_16768437}}, adds the Publication Abstract to the page
+[[Category: Lacticaseibacillus casei]]
-(as it appears on PubMed at http://www.pubmed.gov), where 16768437 is the PubMed ID number.
+[[Category: Large Structures]]
--->
+[[Category: Finer-Moore JS]]
-{{ABSTRACT_PUBMED_16768437}}
+[[Category: Stroud RM]]
-==About this Structure==
-G8D is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Lactobacillus_casei Lactobacillus casei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G8D OCA].
-==Reference==
-The role of protein dynamics in thymidylate synthase catalysis: variants of conserved 2'-deoxyuridine 5'-monophosphate (dUMP)-binding Tyr-261., Newby Z, Lee TT, Morse RJ, Liu Y, Liu L, Venkatraman P, Santi DV, Finer-Moore JS, Stroud RM, Biochemistry. 2006 Jun 20;45(24):7415-28. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16768437 16768437]
-[[Category: Lactobacillus casei]]
-[[Category: Single protein]]
-[[Category: Thymidylate synthase]]
-[[Category: Finer-Moore, J S.]]
-[[Category: Stroud, R M.]]
-[[Category: Active site mutation]]
-[[Category: Alpha/beta protein]]
-[[Category: Beta sheet]]
-[[Category: Dump complex]]
-[[Category: Methyltransferase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:30:28 2008''