2fv8: Difference between revisions

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-{{Seed}}
-[[Image:2fv8.png|left|200px]]
-<!--
+==The crystal structure of RhoB in the GDP-bound state==
-The line below this paragraph, containing "STRUCTURE_2fv8", creates the "Structure Box" on the page.
+<StructureSection load='2fv8' size='340' side='right'caption='[[2fv8]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2fv8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FV8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FV8 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
-{{STRUCTURE_2fv8|  PDB=2fv8  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fv8 OCA], [https://pdbe.org/2fv8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fv8 RCSB], [https://www.ebi.ac.uk/pdbsum/2fv8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fv8 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/RHOB_HUMAN RHOB_HUMAN] Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells.<ref>PMID:9478917</ref> <ref>PMID:10508588</ref> <ref>PMID:15226397</ref> <ref>PMID:16236794</ref> <ref>PMID:21373644</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fv/2fv8_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fv8 ConSurf].
+<div style="clear:both"></div>
-===The crystal structure of RhoB in the GDP-bound state===
+==See Also==
+*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
+*[[Rho GTPase 3D structures|Rho GTPase 3D structures]]
-==About this Structure==
+== References ==
-FV8 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FV8 OCA].
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Arrowsmith, C.]]
+[[Category: Large Structures]]
-[[Category: Bray, J.]]
+[[Category: Arrowsmith C]]
-[[Category: Delft, F von.]]
+[[Category: Bray J]]
-[[Category: Doyle, D.]]
+[[Category: Doyle D]]
-[[Category: Edwards, A.]]
+[[Category: Edwards A]]
-[[Category: Gorrec, F.]]
+[[Category: Gorrec F]]
-[[Category: Johansson, C.]]
+[[Category: Johansson C]]
-[[Category: Papagrigoriou, E.]]
+[[Category: Papagrigoriou E]]
-[[Category: SGC, Structural Genomics Consortium.]]
+[[Category: Schoch G]]
-[[Category: Schoch, G.]]
+[[Category: Smee C]]
-[[Category: Smee, C.]]
+[[Category: Soundararajan M]]
-[[Category: Soundararajan, M.]]
+[[Category: Sundstrom M]]
-[[Category: Sundstrom, M.]]
+[[Category: Turnbull AP]]
-[[Category: Turnbull, A P.]]
+[[Category: Weigelt J]]
-[[Category: Weigelt, J.]]
+[[Category: Von Delft F]]
-[[Category: Gdp/gtp binding]]
-[[Category: Gtp hydrolysis]]
-[[Category: Rhob]]
-[[Category: Sgc]]
-[[Category: Structural genomic]]
-[[Category: Structural genomics consortium]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 20:14:42 2009''