2fom: Difference between revisions

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-[[Image:2fom.png|left|200px]]
-{{STRUCTURE_2fom|  PDB=2fom  |  SCENE=  }}
+==Dengue Virus NS2B/NS3 Protease==
+<StructureSection load='2fom' size='340' side='right'caption='[[2fom]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
-===Dengue Virus NS2B/NS3 Protease===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2fom]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FOM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FOM FirstGlance]. <br>
-{{ABSTRACT_PUBMED_16532006}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fom FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fom OCA], [https://pdbe.org/2fom PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fom RCSB], [https://www.ebi.ac.uk/pdbsum/2fom PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fom ProSAT]</span></td></tr>
-[[2fom]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FOM OCA].
+</table>
+== Function ==
-==See Also==
+[https://www.uniprot.org/uniprot/Q91H74_9FLAV Q91H74_9FLAV] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774]
-*[[Molecular Playground/Dengue Virus Protease|Molecular Playground/Dengue Virus Protease]]
+== Evolutionary Conservation ==
-*[[Virus protease|Virus protease]]
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
-==Reference==
+  <jmolCheckbox>
-<ref group="xtra">PMID:016532006</ref><references group="xtra"/>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fo/2fom_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fom ConSurf].
+<div style="clear:both"></div>
+__TOC__
+</StructureSection>
 [[Category: Dengue virus 2]]
-[[Category: Flavivirin]]
+[[Category: Large Structures]]
-[[Category: Arcy, A D.]]
+[[Category: D'Arcy A]]
-[[Category: Erbel, P.]]
+[[Category: Erbel P]]
-[[Category: Kroemer, M.]]
+[[Category: Kroemer M]]
-[[Category: Renatus, M.]]
+[[Category: Renatus M]]
-[[Category: Schiering, N.]]
+[[Category: Schiering N]]
-[[Category: Flavivirus]]
-[[Category: Ns2b cofactor]]
-[[Category: Ns3 protease]]
-[[Category: Viral protein-protease complex]]