2fkk: Difference between revisions

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[[Image:2fkk.png|left|200px]]


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==Crystal structure of the C-terminal domain of the bacteriophage T4 gene product 10==
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<StructureSection load='2fkk' size='340' side='right'caption='[[2fkk]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2fkk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FKK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FKK FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PO3:PHOSPHITE+ION'>PO3</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
{{STRUCTURE_2fkk|  PDB=2fkk  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fkk OCA], [https://pdbe.org/2fkk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fkk RCSB], [https://www.ebi.ac.uk/pdbsum/2fkk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fkk ProSAT]</span></td></tr>
 
</table>
===Crystal structure of the C-terminal domain of the bacteriophage T4 gene product 10===
== Function ==
 
[https://www.uniprot.org/uniprot/BP10_BPT4 BP10_BPT4] Baseplate protein that is part of the baseplate wedge and that connects the short tail fibers to the baseplate (PubMed:16554069). During infection, the baseplate undergoes a conformational change from a dome-shaped to a star-shaped structure. At this point, gp10 rotates and acts as a lever that unfolds the short tail fibers, which then interact with host cell surface receptors. Involved in the tail assembly.<ref>PMID:16554069</ref> <ref>PMID:21129200</ref>
 
== Evolutionary Conservation ==
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Check<jmol>
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fk/2fkk_consurf.spt"</scriptWhenChecked>
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    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
2FKK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FKK OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fkk ConSurf].
 
<div style="clear:both"></div>
==Reference==
== References ==
Evolution of bacteriophage tails: Structure of T4 gene product 10., Leiman PG, Shneider MM, Mesyanzhinov VV, Rossmann MG, J Mol Biol. 2006 May 5;358(3):912-21. Epub 2006 Mar 9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16554069 16554069]
<references/>
[[Category: Enterobacteria phage t4]]
__TOC__
[[Category: Single protein]]
</StructureSection>
[[Category: Leiman, P G.]]
[[Category: Escherichia virus T4]]
[[Category: Mesyanzhinov, V V.]]
[[Category: Large Structures]]
[[Category: Rossmann, M G.]]
[[Category: Leiman PG]]
[[Category: Shneider, M M.]]
[[Category: Mesyanzhinov VV]]
[[Category: Bacteriophage t4]]
[[Category: Rossmann MG]]
[[Category: Baseplate]]
[[Category: Shneider MM]]
[[Category: Evolution]]
[[Category: Gp10]]
[[Category: Structural comparison]]
[[Category: Tail]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:24:49 2008''

Latest revision as of 12:24, 14 February 2024

Crystal structure of the C-terminal domain of the bacteriophage T4 gene product 10Crystal structure of the C-terminal domain of the bacteriophage T4 gene product 10

Structural highlights

2fkk is a 1 chain structure with sequence from Escherichia virus T4. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.2Å
Ligands:, , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

BP10_BPT4 Baseplate protein that is part of the baseplate wedge and that connects the short tail fibers to the baseplate (PubMed:16554069). During infection, the baseplate undergoes a conformational change from a dome-shaped to a star-shaped structure. At this point, gp10 rotates and acts as a lever that unfolds the short tail fibers, which then interact with host cell surface receptors. Involved in the tail assembly.[1] [2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Leiman PG, Shneider MM, Mesyanzhinov VV, Rossmann MG. Evolution of bacteriophage tails: Structure of T4 gene product 10. J Mol Biol. 2006 May 5;358(3):912-21. Epub 2006 Mar 9. PMID:16554069 doi:10.1016/j.jmb.2006.02.058
  2. ↑ Leiman PG, Arisaka F, van Raaij MJ, Kostyuchenko VA, Aksyuk AA, Kanamaru S, Rossmann MG. Morphogenesis of the T4 tail and tail fibers. Virol J. 2010 Dec 3;7:355. doi: 10.1186/1743-422X-7-355. PMID:21129200 doi:10.1186/1743-422X-7-355

2fkk, resolution 1.20Å

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