2fji: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
New page: left|200px<br /><applet load="2fji" size="450" color="white" frame="true" align="right" spinBox="true" caption="2fji, resolution 2.40Å" /> '''Crystal structure of...
 
No edit summary
 
(14 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:2fji.gif|left|200px]]<br /><applet load="2fji" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2fji, resolution 2.40&Aring;" />
'''Crystal structure of the C-terminal domain of the exocyst subunit Sec6p'''<br />


==Overview==
==Crystal structure of the C-terminal domain of the exocyst subunit Sec6p==
The exocyst is a conserved protein complex essential for trafficking, secretory vesicles to the plasma membrane. The structure of the C-terminal, domain of the exocyst subunit Sec6p reveals multiple helical bundles, which are structurally and topologically similar to Exo70p and the, C-terminal domains of Exo84p and Sec15, despite &lt;10% sequence identity., The helical bundles appear to be evolutionarily related molecular, scaffolds that have diverged to create functionally distinct exocyst, proteins.
<StructureSection load='2fji' size='340' side='right'caption='[[2fji]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[2fji]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FJI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FJI FirstGlance]. <br>
2FJI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2FJI OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fji OCA], [https://pdbe.org/2fji PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fji RCSB], [https://www.ebi.ac.uk/pdbsum/2fji PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fji ProSAT]</span></td></tr>
==Reference==
</table>
The structure of the exocyst subunit Sec6p defines a conserved architecture with diverse roles., Sivaram MV, Furgason ML, Brewer DN, Munson M, Nat Struct Mol Biol. 2006 Jun;13(6):555-6. Epub 2006 May 14. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16699513 16699513]
== Function ==
[https://www.uniprot.org/uniprot/SEC6_YEAST SEC6_YEAST] Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fj/2fji_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fji ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Single protein]]
[[Category: Munson M]]
[[Category: Munson, M.]]
[[Category: Sivaram MV]]
[[Category: Sivaram, M.V.]]
[[Category: exocyst complex]]
[[Category: exocytosis]]
[[Category: tandem helical bundles]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 10:35:15 2007''

Latest revision as of 12:23, 14 February 2024

Crystal structure of the C-terminal domain of the exocyst subunit Sec6pCrystal structure of the C-terminal domain of the exocyst subunit Sec6p

Structural highlights

2fji is a 2 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.4Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SEC6_YEAST Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

2fji, resolution 2.40Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=2fji&oldid=4058454"