2fji: Difference between revisions

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-[[Image:2fji.gif|left|200px]]
- {{Structure
+==Crystal structure of the C-terminal domain of the exocyst subunit Sec6p==
-|PDB= 2fji |SIZE=350|CAPTION= <scene name='initialview01'>2fji</scene>, resolution 2.40&Aring;
+<StructureSection load='2fji' size='340' side='right'caption='[[2fji]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND=
+<table><tr><td colspan='2'>[[2fji]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FJI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FJI FirstGlance]. <br>
-|ACTIVITY=
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
-|GENE= SEC6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fji OCA], [https://pdbe.org/2fji PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fji RCSB], [https://www.ebi.ac.uk/pdbsum/2fji PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fji ProSAT]</span></td></tr>
-|DOMAIN=
+</table>
-|RELATEDENTRY=
+== Function ==
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fji OCA], [http://www.ebi.ac.uk/pdbsum/2fji PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2fji RCSB]</span>
+[https://www.uniprot.org/uniprot/SEC6_YEAST SEC6_YEAST] Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
-}}
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
-'''Crystal structure of the C-terminal domain of the exocyst subunit Sec6p'''
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fj/2fji_consurf.spt"</scriptWhenChecked>
-==Overview==
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-The exocyst is a conserved protein complex essential for trafficking secretory vesicles to the plasma membrane. The structure of the C-terminal domain of the exocyst subunit Sec6p reveals multiple helical bundles, which are structurally and topologically similar to Exo70p and the C-terminal domains of Exo84p and Sec15, despite &lt;10% sequence identity. The helical bundles appear to be evolutionarily related molecular scaffolds that have diverged to create functionally distinct exocyst proteins.
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
-==About this Structure==
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fji ConSurf].
-FJI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FJI OCA].
+<div style="clear:both"></div>
+__TOC__
-==Reference==
+</StructureSection>
-The structure of the exocyst subunit Sec6p defines a conserved architecture with diverse roles., Sivaram MV, Furgason ML, Brewer DN, Munson M, Nat Struct Mol Biol. 2006 Jun;13(6):555-6. Epub 2006 May 14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16699513 16699513]
+[[Category: Large Structures]]
 [[Category: Saccharomyces cerevisiae]]
-[[Category: Single protein]]
+[[Category: Munson M]]
-[[Category: Munson, M.]]
+[[Category: Sivaram MV]]
-[[Category: Sivaram, M V.]]
-[[Category: exocyst complex]]
-[[Category: exocytosis]]
-[[Category: tandem helical bundle]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:03:38 2008''