2ffx: Difference between revisions

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-[[Image:2ffx.png|left|200px]]
-<!--
+==Structure of Human Ferritin L. Chain==
-The line below this paragraph, containing "STRUCTURE_2ffx", creates the "Structure Box" on the page.
+<StructureSection load='2ffx' size='340' side='right'caption='[[2ffx]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2ffx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FFX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FFX FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-{{STRUCTURE_2ffx|  PDB=2ffx  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ffx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ffx OCA], [https://pdbe.org/2ffx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ffx RCSB], [https://www.ebi.ac.uk/pdbsum/2ffx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ffx ProSAT]</span></td></tr>
+</table>
-===Structure of Human Ferritin L. Chain===
+== Disease ==
+[https://www.uniprot.org/uniprot/FRIL_HUMAN FRIL_HUMAN] Defects in FTL are the cause of hereditary hyperferritinemia-cataract syndrome (HHCS) [MIM:[https://omim.org/entry/600886 600886]. It is an autosomal dominant disease characterized by early-onset bilateral cataract. Affected patients have elevated level of circulating ferritin. HHCS is caused by mutations in the iron responsive element (IRE) of the FTL gene.<ref>PMID:20159981</ref>   Defects in FTL are the cause of neurodegeneration with brain iron accumulation type 3 (NBIA3) [MIM:[https://omim.org/entry/606159 606159]; also known as adult-onset basal ganglia disease. It is a movement disorder with heterogeneous presentations starting in the fourth to sixth decade. It is characterized by a variety of neurological signs including parkinsonism, ataxia, corticospinal signs, mild nonprogressive cognitive deficit and episodic psychosis. It is linked with decreased serum ferritin levels.<ref>PMID:20159981</ref> <ref>PMID:16116125</ref>
+== Function ==
-<!--
+[https://www.uniprot.org/uniprot/FRIL_HUMAN FRIL_HUMAN] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).<ref>PMID:19923220</ref> <ref>PMID:20159981</ref>
-The line below this paragraph, {{ABSTRACT_PUBMED_16790936}}, adds the Publication Abstract to the page
+== Evolutionary Conservation ==
-(as it appears on PubMed at http://www.pubmed.gov), where 16790936 is the PubMed ID number.
+[[Image:Consurf_key_small.gif|200px|right]]
--->
+Check<jmol>
-{{ABSTRACT_PUBMED_16790936}}
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ff/2ffx_consurf.spt"</scriptWhenChecked>
-==About this Structure==
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-[[2ffx]] is a 1 chain structure of [[Ferritin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FFX OCA].
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ffx ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Ferritin]]
+*[[Ferritin 3D structures|Ferritin 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:016790936</ref><references group="xtra"/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Carter, D C.]]
+[[Category: Large Structures]]
-[[Category: Ellenburg, M P.]]
+[[Category: Carter DC]]
-[[Category: Ho, J X.]]
+[[Category: Ellenburg MP]]
-[[Category: Li, C.]]
+[[Category: Ho JX]]
-[[Category: Ruble, J R.]]
+[[Category: Li C]]
-[[Category: Soitsman, E M.]]
+[[Category: Ruble JR]]
-[[Category: Wang, Z M.]]
+[[Category: Soitsman EM]]
-[[Category: Wright, B S.]]
+[[Category: Wang ZM]]
-[[Category: Human ferritin light chain perdeuterated capsid]]
+[[Category: Wright BS]]
-[[Category: Metal binding protein]]