2ffl: Difference between revisions

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[[Image:2ffl.png|left|200px]]


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==Crystal Structure of Dicer from Giardia intestinalis==
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<StructureSection load='2ffl' size='340' side='right'caption='[[2ffl]], [[Resolution|resolution]] 3.33&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2ffl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Giardia_intestinalis Giardia intestinalis]. The February 2008 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Small Interfering RNA''  by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2008_2 10.2210/rcsb_pdb/mom_2008_2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FFL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FFL FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.33&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
{{STRUCTURE_2ffl|  PDB=2ffl  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ffl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ffl OCA], [https://pdbe.org/2ffl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ffl RCSB], [https://www.ebi.ac.uk/pdbsum/2ffl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ffl ProSAT]</span></td></tr>
 
</table>
===Crystal Structure of Dicer from Giardia intestinalis===
== Function ==
 
[https://www.uniprot.org/uniprot/DCL_GIAIC DCL_GIAIC] Involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. It produces 21 to 23 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs.<ref>PMID:16410517</ref>
 
== References ==
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{{ABSTRACT_PUBMED_16410517}}
 
==About this Structure==
2FFL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Giardia_intestinalis Giardia intestinalis]. Additional information on 2FFL is available in a page on [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb98_1.html Small Interfering RNA] at the RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FFL OCA].  
 
==Reference==
Structural basis for double-stranded RNA processing by Dicer., Macrae IJ, Zhou K, Li F, Repic A, Brooks AN, Cande WZ, Adams PD, Doudna JA, Science. 2006 Jan 13;311(5758):195-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16410517 16410517]
[[Category: Giardia intestinalis]]
[[Category: Giardia intestinalis]]
[[Category: Ribonuclease III]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: Small Interfering RNA]]
[[Category: Small Interfering RNA]]
[[Category: Adams, P D.]]
[[Category: Adams PD]]
[[Category: Doudna, J A.]]
[[Category: Doudna JA]]
[[Category: MacRae, I J.]]
[[Category: MacRae IJ]]
[[Category: Paz domain]]
[[Category: Rna interference]]
[[Category: Rnai]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 23 10:52:09 2008''

Latest revision as of 12:23, 14 February 2024

Crystal Structure of Dicer from Giardia intestinalisCrystal Structure of Dicer from Giardia intestinalis

Structural highlights

2ffl is a 4 chain structure with sequence from Giardia intestinalis. The February 2008 RCSB PDB Molecule of the Month feature on Small Interfering RNA by David S. Goodsell is 10.2210/rcsb_pdb/mom_2008_2. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3.33Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DCL_GIAIC Involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. It produces 21 to 23 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs.[1]

References

  1. ↑ Macrae IJ, Zhou K, Li F, Repic A, Brooks AN, Cande WZ, Adams PD, Doudna JA. Structural basis for double-stranded RNA processing by Dicer. Science. 2006 Jan 13;311(5758):195-8. PMID:16410517 doi:311/5758/195

2ffl, resolution 3.33Å

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