2f6h: Difference between revisions

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-{{Seed}}
-[[Image:2f6h.png|left|200px]]
-<!--
+==Myosin V cargo binding domain==
-The line below this paragraph, containing "STRUCTURE_2f6h", creates the "Structure Box" on the page.
+<StructureSection load='2f6h' size='340' side='right'caption='[[2f6h]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2f6h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F6H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F6H FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f6h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f6h OCA], [https://pdbe.org/2f6h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f6h RCSB], [https://www.ebi.ac.uk/pdbsum/2f6h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f6h ProSAT]</span></td></tr>
-{{STRUCTURE_2f6h|  PDB=2f6h  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/MYO2_YEAST MYO2_YEAST] Myosin heavy chain that is required for the cell cycle-regulated transport of various organelles and proteins for their segregation. Functions by binding with its tail domain to receptor proteins on organelles and exerting force with its N-terminal motor domain against actin filaments, thereby transporting its cargo along polarized actin cables. Essential for the delivery of secretory vesicles to sites of active growth during bud emergence and cytokinesis. Required for segregation and inheritance of peroxisomes, late Golgi compartments, mitochondria and the vacuole to the daughter cell during cell division. Also required for correct alignment of the spindle during mitosis.<ref>PMID:10931864</ref> <ref>PMID:11285273</ref> <ref>PMID:11381095</ref> <ref>PMID:11733545</ref> <ref>PMID:11781333</ref> <ref>PMID:12391144</ref> <ref>PMID:12743102</ref> <ref>PMID:21248204</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f6/2f6h_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f6h ConSurf].
+<div style="clear:both"></div>
-===Myosin V cargo binding domain===
+==See Also==
+*[[Myosin 3D Structures|Myosin 3D Structures]]
+== References ==
-<!--
+<references/>
-The line below this paragraph, {{ABSTRACT_PUBMED_16437158}}, adds the Publication Abstract to the page
+__TOC__
-(as it appears on PubMed at http://www.pubmed.gov), where 16437158 is the PubMed ID number.
+</StructureSection>
--->
+[[Category: Large Structures]]
-{{ABSTRACT_PUBMED_16437158}}
-==About this Structure==
-F6H is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F6H OCA].
-==Reference==
-Structural basis for myosin V discrimination between distinct cargoes., Pashkova N, Jin Y, Ramaswamy S, Weisman LS, EMBO J. 2006 Feb 22;25(4):693-700. Epub 2006 Jan 26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16437158 16437158]
 [[Category: Saccharomyces cerevisiae]]
-[[Category: Single protein]]
+[[Category: Jin Y]]
-[[Category: Jin, Y.]]
+[[Category: Pashkova N]]
-[[Category: Pashkova, N.]]
+[[Category: Ramaswamy S]]
-[[Category: Ramaswamy, S.]]
+[[Category: Weisman LS]]
-[[Category: Weisman, L S.]]
-[[Category: Cargo binding]]
-[[Category: Cargo transport]]
-[[Category: Mysoin v]]
-[[Category: Secreatory vescile binding]]
-[[Category: Vacuole binding]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:06:14 2008''