2euf: Difference between revisions

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-[[Image:2euf.png|left|200px]]
-{{STRUCTURE_2euf|  PDB=2euf  |  SCENE=  }}
+==X-ray structure of human CDK6-Vcyclin in complex with the inhibitor PD0332991==
+<StructureSection load='2euf' size='340' side='right'caption='[[2euf]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
-===X-ray structure of human CDK6-Vcyclin in complex with the inhibitor PD0332991===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2euf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Herpesvirus_saimiri_(strain_11) Herpesvirus saimiri (strain 11)] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EUF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EUF FirstGlance]. <br>
-{{ABSTRACT_PUBMED_16789739}}
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=LQQ:6-ACETYL-8-CYCLOPENTYL-5-METHYL-2-[(5-PIPERAZIN-1-YLPYRIDIN-2-YL)AMINO]PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE'>LQQ</scene></td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2euf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2euf OCA], [https://pdbe.org/2euf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2euf RCSB], [https://www.ebi.ac.uk/pdbsum/2euf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2euf ProSAT]</span></td></tr>
-[[2euf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EUF OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CGH2_SHV21 CGH2_SHV21] May be highly relevant to the process of cellular transformation and rapid T-cell proliferation effected by HVS during latent infections of T-cells in susceptible hosts.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eu/2euf_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2euf ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Cyclin|Cyclin]]
+*[[Cyclin 3D structures|Cyclin 3D structures]]
+*[[Cyclin-dependent kinase 3D structures|Cyclin-dependent kinase 3D structures]]
-==Reference==
+__TOC__
-<ref group="xtra">PMID:016789739</ref><references group="xtra"/>
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Non-specific serine/threonine protein kinase]]
+[[Category: Large Structures]]
-[[Category: Viruses]]
+[[Category: Lu H]]
-[[Category: Lu, H.]]
+[[Category: Schulze-Gahmen U]]
-[[Category: Schulze-Gahmen, U.]]
-[[Category: Cell cycle-transferase complex]]
-[[Category: Inhibitor complex of human cyclin-dependent kinase 6]]